PFAS & Birth Weight

[Raul]

Below are just a few of the recent studies documenting birth weight alterations associated with PFAS.

Cao T, Qu A, Li Z, Wang W, Liu R, Wang X, Nie Y, Sun S, Zhang X, Liu X - "The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis" Environ Sci Pollut Res Int 28(47):67053-67065 (2021). doi: 10.1007/s11356-021-15061-4
https://link.springer.com/article/10.10 ... 21-15061-4
(Trimester not considered)

Dai Y, Zhang J, Wang Z, Ding J, Xu S, Zhang B, Guo J, Qi X, Chang X, Wu C, Zhou Z - "Per- and polyfluoroalkyl substances in umbilical cord serum and body mass index trajectories from birth to age 10 years: Findings from a longitudinal birth cohort (SMBCS)" Environ Int 180:108238 (2023). doi: 10.1016/j.envint.2023.108238
https://www.sciencedirect.com/science/a ... 2023005111

Fan X, Tang S, Wang Y, Fan W, Ben Y, Naidu R, Dong Z - "Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight" Environ Sci Technol 56(7):4282-4294 (2022). doi: 10.1021/acs.est.1c08669
https://pubs.acs.org/doi/10.1021/acs.est.1c08669

Gao X, Ni W, Zhu S, Wu Y, Cui Y, Ma J, Liu Y, Qiao J, Ye Y, Yang P, Liu C, Zeng F - "Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis." Environ Res 201:111632 (2021). doi: 10.1016/j.envres.2021.111632
https://linkinghub.elsevier.com/retriev ... 21)00926-9
(Trimester not considered)

Manea S, Salmaso L, Lorenzoni G, Mazzucato M, Russo F, Mantoan D, Martuzzi M, Fletcher T, Facchin P - "Exposure to PFAS and small for gestational age new-borns: A birth records study in Veneto Region (Italy)" Environ Res 184:109282 (2020). doi: 10.1016/j.envres.2020.109282
https://www.sciencedirect.com/science/a ... 5120301754

Padula AM, Ning X, Bakre S, Barrett ES, Bastain T, Bennett DH, Bloom MS, Breton CV, Dunlop AL, Eick SM, Ferrara A, Fleisch A, Geiger S, Goin DE, Kannan K, Karagas MR, Korrick S, Meeker JD, Morello-Frosch R, O'Connor TG, Oken E, Robinson M, Romano ME, Schantz SL, Schmidt RJ, Starling AP, Zhu Y, Hamra GB, Woodruff TJ; program collaborators for Environmental influences on Child Health Outcomes - "Birth Outcomes in Relation to Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Stress in the Environmental Influences on Child Health Outcomes (ECHO) Program" Environ Health Perspect 131(3):37006 (2023). doi: 10.1289/EHP10723
https://pubmed.ncbi.nlm.nih.gov/36920051/
(Trimester not considered)

Tian Y, Zhou Q, Zhang L, Li W, Yin S, Li F, Xu C - "In utero exposure to per-/polyfluoroalkyl substances (PFASs): Preeclampsia in pregnancy and low birth weight for neonates" Chemosphere 313:137490 (2023). doi: 10.1016/j.chemosphere.2022.137490
https://linkinghub.elsevier.com/retriev ... 22)03983-2
Increased LBW risks were found for preeclampsia and higher exposure of PFOA - effects differing by sex.
(3rd Trimester)

Wang Z, Luo J, Zhang Y, Li J, Zhang J, Tian Y, Gao Y; Shanghai Birth Cohort - "High maternal glucose exacerbates the association between prenatal per- and polyfluoroalkyl substance exposure and reduced birth weight" Sci Total Environ 858(Pt 3):160130 (2023). doi: 10.1016/j.scitotenv.2022.160130
https://linkinghub.elsevier.com/retriev ... 22)07230-8

Wang Z, Yang W, Xu M, Li B, Chen M, Hu J, Wu P, Wu W - "Associations between gestational exposure to perfluoroalkyl substances, fetal growth, and the mediation effect of thyroid hormones" Sci Rep 14(1):25176 (2024). doi: 10.1038/s41598-024-75210-w.
https://www.nature.com/articles/s41598-024-75210-w
"Maternal free triiodothyronine (FT3) mediated 36.7% of the negative association between PFNA and birth length, and free thyroxine (FT4) mediated 30.8% of the effect of PFOA on head circumference. When performing stratified analysis by infant sex, the associations might differ between boys and girls."
(1st Trimester)

Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL - "Prenatal Exposure to Perfluorocarboxylic Acids (PFCAs) and Fetal and Postnatal Growth in the Taiwan Maternal and Infant Cohort Study_ Environ Health Perspect 124(11):1794-1800 (2016). doi: 10.1289/ehp.1509998
https://ehp.niehs.nih.gov/doi/10.1289/ehp.1509998
(3rd Trimester)

Wright JM, Lee AL, Rappazzo KM, Ru H, Radke EG, Bateson TF - "Systematic review and meta-analysis of birth weight and PFNA exposures." Environ Res. 222:115357 (2023). doi: 10.1016/j.envres.2023.115357
https://www.sciencedirect.com/science/a ... 5123001494

Zhang Y, Mustieles V, Sun Q, Coull B, McElrath T, Rifas-Shiman SL, Martin L, Sun Y, Wang YX, Oken E, Cardenas A, Messerlian C - "Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes" JAMA Netw Open 6(5):e2314934 (2023). doi: 10.1001/jamanetworkopen.2023.14934
https://jamanetwork.com/journals/jamane ... le/2805449
(1st Trimester)


Zheng T, Kelsey K, Zhu C, Pennell KD, Yao Q, Manz KE, Zheng YF, Braun JM, Liu Y, Papandonatos G, Liu Q, Shi K, Brochman S, Buka SL - "Adverse birth outcomes related to concentrations of per- and polyfluoroalkyl substances (PFAS) in maternal blood collected from pregnant women in 1960-1966" Environ Res 241:117010 (2023) doi: 10.1016/j.envres.2023.117010
https://linkinghub.elsevier.com/retriev ... 23)01814-5
"Maternal PFAS levels from the 1960s exceeded values in contemporaneous populations and 2) that gestational concentrations of certain PFAS were associated with lower birth weight and infant ponderal index."
(Trimester not considered)


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Conley JM, Lambright CS, Evans N, McCord J, Strynar MJ, Hill D, Medlock-Kakaley E, Wilson VS, Gray LE Jr - "Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat" Environ Int 146:106204 (2021)doi: 10.1016/j.envint.2020.106204
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775906/