Voriconazole induces fluorosis

News about fluorinated drugs
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Voriconazole induces fluorosis

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Rad B, Saleem M, Grant S, Florkowski C, Coates P, Gordon D, Rankin W - "Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment" Ann Clin Biochem 52(Pt 5):611-4 (2015)
https://pubmed.ncbi.nlm.nih.gov/25587196/

We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.
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