2020 - Effect of sodium fluoride on adrenal and thyroid glands in adult male rats

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2020 - Effect of sodium fluoride on adrenal and thyroid glands in adult male rats

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Hameed MA, Hadi KA, Gabori EA, Aziz AA, Obid WS, Hadree DH - "Effect of sodium fluoride on some physiological parameters and histopathology in adrenal and thyroid glands in adult male rats" Basrah Journal of Veterinary Research 19(3) 2020 - Proceeding of the 17th International Conference, College of Veterinary Medicine, University of Basrah, Iraq
https://basjvet.org/uplodes/pdf/1607953396.pdf

This study was carried out to investigate the harmful effect of water fluoridation on both (thyroid and adrenal gland) in adult male rats [weight about (400-300gm)] exposed to sodium fluoride(NaF) in the drinking water. We used in this study adult male rats (albino) that were distributed randomly and divided into two equal groups (15 animals per group). The first group was given normal water and considered as a control group (control group), while the second group were given drinking water with 100 ppm of sodium fluoride(NaF) (treated group). This study was carried out in the animal house in the college of Vet. Med.\ Tikrit University. Blood was drawn through the eye pupil for periods (0,30,60 days) in order to measure the following parameters: Measurement of Glutathione(GSH) concentration, total cholesterol, and blood glucose concentration. In addition, tissue sections were taken of the thyroid and adrenal glands. The results of this study showed that exposure of animals to sodium fluoride at a concentration of 100 ppm in drinking water for (60) days cause adrenal and thyroid gland dysfunction, represented by a significant decrease in the level of glutathione in blood serum on days 30 and 60 of the experiment and a significant increase in total cholesterol and blood glucose concentrations.The results of the histological examination of the thyroid gland of the treated group showed hyperplasia of the epithelial cell layer lining the acini vesicles, and severe lipid changes were seen in the function of Reticularis in the histological sections of the thyroids gland of the same group of animals. The results of this study confirmed the harmful effect of sodium fluoride(NaF) on thyroid and adrenal functions in addition to its effect on some biochemical parameters that are indicative of the occurrence of harmful effects of some chemical compounds.
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