2021: Elevated serum fluoride levels in perimenopausal women are related to the components of metabolic syndrome

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2021: Elevated serum fluoride levels in perimenopausal women are related to the components of metabolic syndrome

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Schneider-Matyka D, Gutowska I, Panczyk M, Grochans E, Szkup M- "Elevated serum fluoride levels in perimenopausal women are related to the components of metabolic syndrome" European Review for Medical and Pharmacological Sciences 25:5474-5482 (2021)
https://www.europeanreview.org/wp/wp-co ... 4-5482.pdf

Abstract

OBJECTIVE: Increased fluoride levels can lead to numerous complications, including skeletal effects, cardiotoxicity, endocrine dysfunction, neurotoxicity, hepatotoxicity and nephrotoxicity. The aim of this study was to analyze the relationship between serum fluoride levels and MetS or its individual components, and to assess the diagnostic usefulness of fluoride as a factor contributing to MetS.

PATIENTS AND METHODS: The study included a group of 475 women (mean age of 52.9 years), living in the West Pomeranian Voivodeship in Poland. The study involved data collection and biochemical analysis.

RESULTS: Analysis of the relationship between the levels of fluoride and the presence of MetS or its components showed that the mean fluoride level was statistically significantly higher in patients with hypertriglyceridemia (dCohen = 0.39; 95% CI; confidence limits: 0.13, 0.63) and hypertension (dCohen = 0.25; 95% CI; confidence limits: 0.07, 0.44). Moreover, the mean fluoride level was significantly higher in women who met the diagnostic criteria for MetS than in the remaining subjects (dCohen = 0.40; 95% CI; confidence limits: 0.17, 0.64).

CONCLUSIONS: Elevated serum fluoride levels may be associated with an increased incidence of MetS among perimenopasal women, although its diagnostic value as a marker of MetS is limited.
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MetS & TSH

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--> Fluoride is a TSH analogue.

The prevalence of MetS and most of its components increases with an elevation of TSH levels - even increases within the "normal" reference range (Li et al., 2020; Ahirwa et al., 2017; Keshkin et al., 2021; Ruhla et al., 2010; Boggio et al.,2014).


TSH

Ahirwar AK, Singh A, Jain A, Patra SK, Goswami B, Bhatnagar MK, Bhattacharjee J - "Raised TSH is associated with endothelial dysfunction in Metabolic Syndrome: A case control study" Rom J Intern Med 55(4):212-221 (2017)
https://pubmed.ncbi.nlm.nih.gov/28640754/

Boggio A, Muzio F, Fiscella M, Sommariva D, Branchi A - "Is thyroid-stimulating hormone within the normal reference range a risk factor for atherosclerosis in women?" Intern Emerg Med 9(1):51-7 (2014)
https://pubmed.ncbi.nlm.nih.gov/22203234/

Keskin H, Cadirci K, Gungor K, Karaaslan T, Usta T, Ozkeskin A, Musayeva A, Yesildal F, Isman F, Zengin HY - "Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome" Int J Endocrinol 2021:8891972 (2021)
https://pubmed.ncbi.nlm.nih.gov/34122543/
"Increased TSH even in the normal range was associated with eGFR after adjusting for age and body mass index (BMI), especially in females. The high age (b = -0.160, p=0.005), high BMI (b = -0.134, p=0.020), high TSH (b = -0.380, p < 0.01), and high uric acid (b = -0.348, p < 0.01) were found as significant predictors of the eGFR in MetS patients."

Li M, Zhang X, Zhou X, Han X, Zhang R, Fu Z, Wang L, Gao Y, Li Y, Ji L - "The Association Between Serum Thyrotropin Within the Reference Range and Metabolic Syndrome in a Community-Based Chinese Population" Diabetes Metab Syndr Obes 13:2001-2011 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articl ... /32606859/
"The prevalence of MetS and most of its components increased in the higher TSH group in euthyroid Chinese population."

Ruhla S, Weickert MO, Arafat AM, Osterhoff M, Isken F, Spranger J, Schöfl C, Pfeiffer AF, Möhlig M - "A high normal TSH is associated with the metabolic syndrome" Clin Endocrinol (Oxf) May;72(5):696-701 (2010)
https://pubmed.ncbi.nlm.nih.gov/20447068/
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