2021 - Dementia induced by a mixture of aluminum, cadmium, and fluoride

Recent Research
Post Reply
pfpcnews
Posts: 997
Joined: Mon Apr 03, 2006 5:50 am

2021 - Dementia induced by a mixture of aluminum, cadmium, and fluoride

Post by pfpcnews »

Hussien HM, Ghareeb DA, Ahmed HEA, Hafez HS, Saleh S - "Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rat" Environ Sci Pollut Res Int. 2021 Jul 7. doi: 10.1007/s11356-021-15193-7. Epub ahead of print. PMID: 34235690. doi: 10.1007/s11356-021-15193-7. Epub ahead of print. PMID: 34235690.
https://pubmed.ncbi.nlm.nih.gov/34235690/

Long-term exposure to environmental neurotoxic metals is implicated in the induction of dementia and cognitive decline. The present study aims to illustrate the therapeutic role of ipriflavone as a synthetic isoflavone against environmental metal–induced cognitive impairment in rats. Dementia was induced by a mixture of aluminum, cadmium, and fluoride for 90 days followed by ipriflavone for a further 30 days. Metal-treated animals exhibited abnormal behaviors in the Morris water maze task. Neuropathological biomarkers including oxidative stress (TBARS, NO, SOD, GPX, GST, and GSH), inflammation (TNF- α, IL-6, and IL-1β), neurotransmission (AChE and MAO), and insulin resistance (insulin, insulin receptor, and insulin-degrading enzyme) were altered, which consequently elevated the level of amyloid-β42 and tau protein in the hippocampus tissues inducing neuronal injury. Ipriflavone significantly (P < 0.05) ameliorated the neurobehavioral abnormalities and the cognitive dysfunction biomarkers via antioxidant/anti-inflammatory mechanism. Moreover, ipriflavone downregulated the mRNA expression level of amyloid precursor protein and tau protein, preventing amyloid plaques and neurofibrillary tangle aggregation at P < 0.05. A molecular docking study revealed that ipriflavone has a potent binding affinity towards AChE more than donepezil and acts as a strong AChE inhibitor. Our data concluded that the therapeutic potential of ipriflavone against dementia could provide a new strategy in AD treatment.

SEE also: Cadmium: viewtopic.php?f=29&t=680
Post Reply