Kumar V, Chahar P, Kajjari S, Rahman F, Bansal DK, Kapadia JM - "Fluoride,
Thyroid Hormone Derangements and its Correlation with Tooth Eruption Pattern
Among the Pediatric Population from Endemic and Non-endemic Fluorosis Areas"
J Contemp Dent Pract 19(12):1512-1516 (2018). PubMed PMID: 30713182
AIM: To comparatively evaluate the status of fluoride in the body with thyroid
activity in the pediatric population of endemic fluorosis areas. The present
study also attempted to elucidate whether any correlation exists between fluoride
and thyroid hormone derangement with delayed tooth eruption.
MATERIALS AND METHODS: A total of 400 pediatric subjects were included in the
present study. All the patients were divided into two broad groups; groups A and
B. Group A included 200 subjects who belonged to the endemic fluorosis area while
Group B included remaining 200 subjects, who belonged to the fluorosis
non-endemic area. Group B subjects were taken as control. Group A subjects were
further divided into two study groups as follows: Group A1: 100 Pediatric
subjects with dental fluorosis, and Group A 2: A total of one hundred pediatric
subjects without dental fluorosis. Dean's index of fluorosis was calculated in
all the patients. Blood samples were collected and were sent to a laboratory for
assessment of thyroid hormone levels. All the results were subjected to
statistical analysis by Statistical Package for the Social Sciences (SPSS)
RESULTS: Mean thyroid stimulating hormone (TSH), water fluoride levels, urine
fluoride levels and serum fluoride levels of subjects in group 1 were found to be
significantly higher than that of subjects of group 2. Delayed tooth eruption was
absent in subjects of group B while it was present in 100 subjects of group A.
Thyroid hormone level derangement was seen in 54 percent subjects of group B,
while it was seen in 67.5% subjects of group A.
CONCLUSION: Positive correlation exists between fluorosis and thyroid functional
activity. However; the tooth eruption pattern is independent up on the thyroid
CLINICAL SIGNIFICANCE: Delayed tooth eruption and alteration in thyroid hormone
levels can occur in subjects of the endemic fluoride areas. Therefore, adequate
measures should be taken for controlling such adverse effects.
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