Effect of curcumin on the thyroid changes induced by NaF

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Effect of curcumin on the thyroid changes induced by NaF

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Abdelaleem MM, El-Tahawy ELM, Abozaid SMM, Abdel-Hakim3 SAB - "Possible protective effect of curcumin on the thyroid gland
changes induced by sodium fluoride in albino rats: light and electron microscopic study" ENDOCRINE REGULATIONS 52:259–68 (2018)
https://www.degruyter.com/downloadpdf/j ... 8-0007.pdf

Objectives. Thyroid gland regulates the body’s metabolic rate and plays an exquisitely important
role in the human health. Fluoride exposure can affect thyroid function. Curcumin is a potent
antioxidant that works through several mechanisms. The aim of the present study was to
demonstrate the hormonal, histological, and ultrastructural changes occurred in the thyroid gland
induced by exposure to sodium fl uoride (NaF) and study the possible protective effect of curcumin
on the NaF-induced effects.
Methods. Thirty male albino rats were randomly divided into 3 equal groups (10 rats each): the
control group, NaF group, and NaF+Curcumin (NaF+Cur) group. Th yroid-stimulating hormone
(TSH), triiodothyronine (T3) and thyroxine (T4) levels were assayed and thyroid tissues processed
for light and transmission electron microscopic study.
Results. In NaF group, serum T3 and T4 levels were significantly decreased whereas TSH level
was significantly increased compared to the control group. Thyroid tissues showed fl attening of the
epithelial lining with several follicular cell degenerations, hyperplasia, decreased colloid, disrupted
basement membrane, cytoplasmic vacuolations, degenerated mitochondria, widening of rough
endoplasmic reticulum cisternae, and vascular congestion compared to the control group. In the
NaF+Cur group, serum TSH levels were significantly decreased in comparison with NaF group
and no significant difference in comparison with the control group. Thyroid sections appeared apparently
normal compared to the control group and NaF group.

Conclusions. Sodium fluoride affected both the function and structure of the thyroid gland
while curcumin was protective against these toxic effects.
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