2015 - Thyroid dysfunction associated with excess F intakes

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2015 - Thyroid dysfunction associated with excess F intakes

Postby pfpcnews » Tue May 12, 2015 2:46 am

Sachdeva S, Ahmed J, Singh B - "Thyroid dysfunction associated with excess fluoride intakes: Scope for primary prevention" Thyroid Res Pract 12:50-6 (2015)
Available from: http://www.thetrp.net/text.asp?2015/12/2/50/156726

Background: Preventable thyroid dysfunction has remained a neglected entity worldwide. Excess fluoride consumption over years leads to irreversible thyroid dysfunction. Materials and Methods: Subjects (N = 275) with thyroid dysfunction were recruited from medicine and endocrinology OPDs/wards and were thoroughly examined. The source and type of water consumed by these subjects was asked and sampled for fluoride analysis. Results: A majority (75%) of the subjects were females. Hypothyroidism including subclinical hypothyroidism was the major underlying dysfunction. Majority of the afflicted (53%) consumed ground water as their predominant drinking water source. Fluoride content was well above acceptable limits of potability (1mg/L) in ground water and this correlated positively with elevated serum thyroid stimulating hormone (TSH) and negatively with free T3 levels in blood. The correlation was statistically significant (P < 0.05). Conclusion: Excess of fluoride in drinking water was the plausible cause of hypothyroidism in study individuals. Fluoridation of water for prevention of dental caries is a policy that can be amended for the sake of this larger picture. Thyroid diseases deserve recognition as non-communicable diseases (NCDs) of public health importance.
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