Multiomics Analysis Revealed the Molecular Mechanism of miRNAs in F-Induced Hepatic Glucose & Lipid Metabolism Disorders

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Multiomics Analysis Revealed the Molecular Mechanism of miRNAs in F-Induced Hepatic Glucose & Lipid Metabolism Disorders

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NOTE: Between 1930 and 1950, German pharmacologists showed that fluoride effects on thyroid hormones were due to its interfering with glycolysis in the liver, the main organ for thyroid hormone metabolism (deiodination). This research led to the use of fluoride in the treatment of iodine-induced hyperthyroidism.

Zhao Y, Yu Y, Ommati MM, Xu J, Wang J, Zhang J, Sun Z, Niu R, Wang J - "Multiomics Analysis Revealed the Molecular Mechanism of miRNAs in Fluoride-Induced Hepatic Glucose and Lipid Metabolism Disorders" J Agric Food Chem. 2022 Oct 12. doi: 10.1021/acs.jafc.2c03049
https://pubs.acs.org/doi/10.1021/acs.jafc.2c03049

Abstract

Fluoride-induced liver injury seriously endangers human and animal health and animal food safety, but the underlying mechanism remains unclear. This study aims to explore the mechanism of miRNAs in fluoride-induced hepatic glycolipid metabolism disorders. C57 male mice were used to establish the fluorosis model (22.62 mg/L F–, 12 weeks). The results indicated that fluoride increased fluoride levels, impaired the structure and function, and disrupted the glycolipid metabolism in the liver. Furthermore, the sequencing results showed that fluoride exposure resulted in the differential expression of 35 miRNAs and 480 mRNAs, of which 23 miRNAs were related to glycolipid metabolism. miRNA–mRNA network analyses and RT-PCR revealed that miRNAs mediated fluoride-induced disturbances in the hepatic glycolipid metabolism. Its possible mechanism was to regulate the insulin pathway, PPAR pathway, and FOXO pathway, which in turn affected the bile secretion, the metabolic processes of glucose, the decomposition of lipids, and the synthesis of unsaturated fatty acids in the liver. This study provides a theoretical basis for miRNAs as diagnostic indicators and target drugs for the treatment of fluoride-induced liver injury.
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