1998 - Timing of F- exposure on pregnant rat thyroid

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1998 - Timing of F- exposure on pregnant rat thyroid

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55. 常青,戎成兴,张世明.不同时间氟暴露对孕鼠甲状腺形态和功能的影响.微量元素与健康研究,1998,15(2):10
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不同时间氟暴露对孕鼠甲状腺形态和功能的影响常青戎诚兴①张世明①(暨南大学医学院广州510632)摘要观察氟对孕鼠甲状腺形态和功能的影响。取受孕后(P1组)或受孕前12周始(P2组)自由饮用200mg/L含氟水小鼠的甲状腺和血清,观察其形态变化,测定血清甲状腺素(T4)水平。结果:P1组甲状腺呈增生性改变,血T4浓度显著高于对照组(C组,P<0.001);P2组部分腺体呈退行性改变,血T4浓度与C组无差别(P>0.05)。提示:氟对孕鼠甲状腺的影响与作用时间有关。关键词氟化物甲状腺妊娠小鼠氟是机体生命活动所必须的微量元素之一,但机体长期摄入过量氟可造成生物体多种组织的损伤,其对甲状腺的危害也早已引起人们的关注[1]。然而其对妊娠期甲状腺产生的影响如何,则鲜见报道。本实验通过观察在不同时间内自由饮用含氟水孕鼠甲状腺的形态和功能变化,从而探讨氟对妊娠期鼠甲状腺所产生的影响及其可能作用机制。材料与方法1实验动物与分组实验选用昆明种小白鼠,鼠龄2~3月,体重25~30g,达性成熟和体成熟。雌鼠随机分为3组:A.正常对照组(C组):交配前后均自由饮用自来水。B.孕期给......(本文共计3页)
wendy
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Google Translation - 55 - Kunming Mice

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Effect of Fluorine Exposure at Different Time on Thyroid Morphology and Function of Pregnant Rats Chang Qingrong Cheng Xing ① Zhang Shiming ① (Jinan University School of Medicine Guangzhou 51063) Abstract Observe the effect of fluoride on thyroid morphology and function of pregnant mice. The thyroid and serum of mice with 200 mg/L fluoride-containing water were taken freely after conception (group P1) or 12 weeks before conception (group P2), and the morphological changes were observed to determine the level of serum thyroxine (T4). Results: The thyroid gland in P1 group showed hyperplastic changes, and the blood T4 concentration was significantly higher than that in the control group (C group, P<0.001); some glands in P2 group showed degenerative changes, and the blood T4 concentration was not different from that in C group (P> 0.05). Tip: The effect of fluoride on the thyroid of pregnant rats is related to the duration of action. Keywords fluoride, thyroid, pregnant mice, fluoride is one of the trace elements necessary for the body's life activities, but long-term intake of excessive fluoride in the body can cause damage to various tissues of the organism, and its harm to the thyroid has long aroused people's attention [ 1]. However, how it affects the thyroid gland during pregnancy is rarely reported. In this experiment, by observing the morphology and function of the thyroid of pregnant rats drinking fluoride-free water freely at different times, the effect of fluoride on the thyroid of pregnant rats and its possible mechanism of action were explored. Materials and methods 1. Experimental animals and group experiments The Kunming mice were selected. The mice were 2 to 3 months old, weighing 25 to 30 g, and reached sexual maturity and body maturity. Female rats are randomly divided into 3 groups: A. Normal control group (Group C): Drink tap water freely before and after mating. B. During pregnancy... (this article has 3 pages)
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