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2009 - Fluoride and Thyroid Hormones in Children

PostPosted: Fri Aug 16, 2013 6:28 pm
by admin
99 . 耿雪.段丽菊.巴月 饮水高氟对儿童甲状腺功能的影响 [期刊论文] -河南预防医学杂志2009(3)
http://d.wanfangdata.com.cn/Periodical_ ... 03003.aspx
Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009)

目的 探讨饮水高氟对儿童甲状腺功能的影响.方法 选择高氟饮水地区和对照地区作为调查点,以当地出生成长的8~12岁儿童作为调查对象;氟离子选择电极法测定尿氟含量,砷铈催化分光光度法测定尿碘含量.按照中甲状腺肿大的诊断标准诊断甲状腺肿大情况,应用放射免疫分析法测定血清中游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FF4)和促甲状腺激素(TSH)三种激素水平.结果 高氟区儿童尿氟含量为2.09 mg/L,对照区儿童尿氟含量为0.83mg/L,两者差异有统计学意义(P<0.05);高氟区儿童尿碘含量为294.85 mg/L,对照区儿童尿碘含量为468.82 ms/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT3的浓度为5.73 pmol/L,对照区儿童血清FT3的浓度为4.60 pmol/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT4的浓度为7.40 pmol/L,对照区儿童血清FT4的浓度为8.07 pmol/L,两者差异无统计学意义(p>0.05);高氟区儿童血清TSH的浓度为1.03 pmol/L,对照区儿童血清TSH的浓度为1.10 pmol/L,两者差异无统计学意义(p>0.05);高氟区和对照区儿童甲状腺肿大差异无统计学意义(p>0.05).结论 饮水高氟可影响儿童血清F13水平.

Re: 2009 - Fluoride and Thyroid Hormones in Children

PostPosted: Tue Jun 23, 2020 10:27 pm
by admin
Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009)

(Area with excessine iodine ingestion)

Objective To explore the effect of drinking high fluoride on thyroid function in children. Methods The high-fluorine drinking water area and the control area were selected as the survey points, and the children aged 8 to 12 years old who were born and raised in the area were selected as the survey objects. According to the diagnostic criteria for goiter in GB16004-1995, goiter was diagnosed, and radioimmunoassay was used to determine free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone in serum. TSH) Three hormone levels. Results The urinary fluoride content of children in the high fluoride area was 2.09 mg/L, and the urinary fluoride content of children in the control area was 0.83 mg/L, the difference was statistically significant (p0.05); the urinary iodine content of children in the high fluoride area was 294.85 mg/L L, the urine iodine content of children in the control area was 468.82 mg/L, the difference between the two was statistically significant (P0.05); the concentration of serum FT3 in children in the high fluoride area was 5.73 pmol/L, and the concentration of serum FT 3 in the control area was 4.60 pmol/L, the difference between the two was statistically significant (P0.05); the concentration of children's serum FT4 in the high fluoride area was 7.40 pmol/L, and the concentration of children's serum FT4 in the control area was 8.07 pmol/L, and there was no difference between the two Academic significance (p0.05); the concentration of children's serum TSH in the high fluoride area was 1.03 pmol/L, and the concentration of children's serum TSH in the control area was 1.10 pmol/L, the difference between the two was not statistically significant (p0.05); high fluoride There was no significant difference in children's goiter between the area and the control area (p0.05). Conclusion High fluoride in drinking water can affect the serum FT3 level in children.

UF: 2.09 - 0.83 mg/L
UI: 294.85 - 468.82 mg/L
FT4: 7.40 pmol - 8.07 pmol
FT3: 5.73 pmol - 4.60 pmol
TSH: 1.03 - 1.10