2016 - FX of High F/I on immune system - IL-21

2016 - FX of High F/I on immune system - IL-21

Postby admin » Fri Jul 17, 2020 2:10 am

206. 侯国强,陈玕,孙宁,等.饮用水高氟碘对8-10岁儿童血清免疫物质水平的影响[J].当代医学,2016(30):3-4.
Hou Guoqiang, Chen Gan, Sun Ning, Zhang L,i Liu Yang - "The effect of drinking water high fluoride/iodine on the level of serum immune substances in 8-10 year old children" Contemporary Medicine" (30):3-4 (2016)
http://www.cqvip.com/QK/90953A/201630/670276412.html
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摘 要:目的 研究自然条件下,饮水高氟、碘对8-10岁儿童血清白细胞介素21(IL-21)水平及IgM、IgG含量的影响。方法 选择饮水氟〉2.0 mg/L、碘中位数〉150 mg/L自然村8-10岁儿童90名为研究组,饮水氟〈1.0 mg/L、碘中位数50-80 mg/L自然村8-10岁儿童90名为对照组,检测其血液中IL-21水平及IgM、IgG含量。结果 研究组儿童IL-21测定结果范围为432.4-7 790.9 pg/mL,中位数为912.01 pg/mL,对照组测定结果范围为302.3-4 324.8 pg/mL,中位数为588.84 pg/mL,二者差异有统计学意义(P〈0.01);研究组IgM含量1.11-4.02 mg/mL,对照组0.78-3.54 mg/mL,二者差异无统计学意义;研究组IgG含量8.81-19.98 mg/mL,中位数为13.34 mg/mL,对照组7.14-20.46 mg/mL,中位数为12.53 mg/mL,二者差异有统计学意义(P〈0.05)。结论 自然状态条件下,饮水高氟、碘时8-10岁儿童IL-21水平明显升高,从而抑制自体免疫水平,致使血清IgG含量明显降低,但对IgM含量尚无明显影响,提示饮水高氟碘将导致8-10岁儿童自体免疫水平降低。
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