2012 Effects of high F and I on TH and intellectual develop.

2012 Effects of high F and I on TH and intellectual develop.

Postby admin » Sat Jun 27, 2020 10:25 pm

200. 《天津医科大学》 2012年收藏
王睿 - 高氟高碘联合对甲状腺损害和智力发育影响
http://cdmd.cnki.com.cn/Article/CDMD-10 ... 503360.htm
Wang R - "Effect of combination of high fluoride and iodine on thyroid damage and intellectual development" (2012) Master Thesis, Tianjin Med University

摘要】:目的 研究高氟单独及与高碘联合慢性暴露对儿童甲状腺损害和智力发育的影响,以进一步探讨高氟高碘联合暴露的健康效应,为寻找高氟高碘损害的早期生物标志物提供佐证。 方法 在天津市静海县和武清区的高氟区、高氟高碘区及对照区中选择四所学校,分别在每个学校三、四年级中选择本地出生的8-10岁儿童,共计98名研究对象。对选定的研究对象进行体格发育、氟斑牙患病情况检查、并采用《中国联合型瑞文测验(CRT-C2图册)》(中国农村版)进行智力水平测试。对研究对象的饮水情况进行问卷调查,采集其所在村镇的水源水、学校饮用水及家庭用盐。采集晨尿并抽取晨起空腹静脉血,运用氟离子选择电极法检测尿氟,砷铈氧化还原法测定尿碘;采用放射免疫分析法(RIA)测定血清中激素水平包括三碘甲腺原氨酸(triiodothyronine,T3)、四碘甲腺原氨酸(thyroxine,T4)、促甲状腺激素(thyroid stimulating hormone,TSH)、游离T3(free Triiodothyronine,FT3)、游离T4(free Thyroxine, FT4);采用硫酸巴比妥酸比色法(TBA法)检测丙二醛(MDA)含量、黄嘌呤氧化酶法检测超氧化物歧化酶(SOD)活性、酶联免疫法(ELISA)检测活性氧(ROS)水平。调查结果及实验室数据全部输入数据库,采用SPSS软件进行统计分析。 结果 1高氟高碘组、高氟组合格碘盐食用率低于对照组(P0.05),儿童饮水情况分布三组间差异无统计学意义(P0.05)。 2高氟高碘组、高氟组尿碘和尿氟水平均高于对照组(P0.05);血清甲状腺激素水平除高氟高碘组的血清T4高于高氟组外,其余四项指标(T3、FT3、FT4、TSH)在组间差异无统计学意义(P0.05)。 3高氟组氟斑牙患病率高于高氟高碘组(P0.05),且氟斑牙患病程度与年龄呈正相关。 4高氟高碘组、高氟组儿童智力水平均低于对照组(P0.05),高氟高碘组儿童系列关系能力测验的得分值低于高氟组和对照组(P0.05)。 5高氟高碘组ROS高于高氟组和对照组(P0.05),高氟组SOD活性高于高氟高碘组和对照组(P0.05),三组间儿童血清MDA含量的差异无统计学意义(P0.05)。 6尿碘与ROS呈正相关关系(P0.05),与SOD呈负相关关系(P0.05)。 结论 1高氟单独和与高碘联合慢性暴露对儿童甲状腺功能产生了一定的影响,甲状腺激素水平除T4外没有明显差异。 2高氟高碘慢性暴露对儿童智力发育在一定程度上显示有联合作用,且以系列关系、比拟、图形套合等抽象推理能力方面损伤为主。 3氧化应激与尿氟、尿碘关系密切,ROS、SOD可作为高氟高碘损害的早期生物标志物。 项目来源:天津市医药卫生2010年度科技攻关项目(10KG215)
admin
Site Admin
 
Posts: 1937
Joined: Tue Jan 18, 2005 10:25 pm

Google Translate 200

Postby admin » Sat Jun 27, 2020 10:26 pm

:Objective To study the effect of chronic exposure of high fluoride alone and combined with high iodine on children's thyroid damage and intellectual development, to further explore the health effects of high fluoride and high iodine combined exposure, and to provide evidence for the search for early biomarkers of high fluoride and high iodine damage. Methods Four schools were selected in the high fluoride area, high fluoride high iodine area and control area in Jinghai County and Wuqing District of Tianjin City, and the local born children aged 8-10 years were selected in the third and fourth grades of each school, totaling 98 research subjects. The selected research subjects were examined for physical development and dental fluorosis prevalence, and the "China Combined Raven Test (CRT-C2 Atlas)" (China Rural Version) was used for intelligence level tests. A questionnaire survey was conducted on the drinking water of the research subjects to collect the source water, school drinking water and household salt in the villages and towns where they were located. Collect morning urine and draw fasting venous blood from morning, use fluoride ion selective electrode method to detect urine fluoride, arsenic-cerium redox method to determine urine iodine; use radioimmunoassay (RIA) to determine serum hormone levels including triiodothyronine Acid (triiodothyronine, T3), tetraiodothyronine (thyroxine, T4), thyroid stimulating hormone (TSH), free T3 (free Triiodothyronine, FT3), free T4 (free Thyroxine, FT4); adopted Barbituric acid colorimetric method (TBA method) to detect malondialdehyde (MDA) content, xanthine oxidase method to detect superoxide dismutase (SOD) activity, enzyme-linked immunoassay (ELISA) to detect reactive oxygen species (ROS) Level. The survey results and laboratory data were all input into the database, and SPSS software was used for statistical analysis. Results 1. The consumption rate of high fluoride and high iodine group and high fluoride combination iodized salt was lower than that of the control group (P<0.05). There was no statistically significant difference in the distribution of drinking water among the three groups (P<0.05). 2 Urine iodine and urine fluoride levels in the high-fluorine and high-iodine group and the high-fluorine group were higher than those in the control group (P<0.05); the serum thyroid hormone levels except the high-fluorine and high-iodine group had higher serum T4 than the high-fluorine group. The indexes (T3, FT3, FT4, TSH) were not statistically different between groups (P<0.05). 3 The prevalence of dental fluorosis in the high fluoride group is higher than that in the high fluoride and iodine group (P<0.05), and the prevalence of dental fluorosis is positively correlated with age. 4 The intelligence level of children in the high fluoride and high iodine group and the high fluoride group is lower than that in the control group (P<0.05), Children in the high-fluoride and high-iodine group had lower scores in the series of relationship ability tests than those in the high-fluoride and control groups (P<0.05). 5 ROS in the high fluoride and high iodine group was higher than that in the high fluoride and control groups (P<0.05), and the SOD activity in the high fluoride and high iodine group was higher than that in the high fluoride and high iodine groups and control groups (P<0.05). The difference was not statistically significant (P<0.05). 6 Urinary iodine was positively correlated with ROS (P<0.05) and negatively correlated with SOD (P<0.05). Conclusion 1 Chronic exposure of high fluoride alone and combined with high iodine has a certain effect on children's thyroid function. There is no significant difference in thyroid hormone level except T4. 2 Chronic exposure to high fluoride and iodine has a joint effect on children's intelligence development to a certain extent, and it is mainly damaged by abstract reasoning ability such as series relationship, comparison, and graphics fit. 3 Oxidative stress is closely related to urinary fluoride and urinary iodine. ROS and SOD can be used as early biomarkers of high fluoride and iodine damage. Project source: Tianjin Science and Technology 2010 Science and Technology Research Project (10KG215)
admin
Site Admin
 
Posts: 1937
Joined: Tue Jan 18, 2005 10:25 pm


Return to More Research from China

Who is online

Users browsing this forum: No registered users and 4 guests