Yu Lin-yu, Liu Hong-liang, Wang Rui.et al,- "Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin". Chinese Journal of Public Health 30(2): 212-215 (2014)
http://www.zgggws.com/en/article/doi/10 ... 4-30-02-26
Objective: To investigate the joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin.
Methods: According to the concentration of fluoride and iodine in drinking water, four small towns in two counties of Tianjin were classified into three groups of high fluoride and iodine,high fluride,and control. Children aged 8-10 years in the four towns were chosen. The morning urine was collected and venous blood was taken from the children before breakfast. The concentrations of urinary fluoride,urinary iodine, triiodothyronine (T3),thyroxine (T4), thyroid stimulating hormone (TSH), free T3(FT3), and free T4(FT4) in the serum were detected. Maleicdialdehyde(MDA), superoxide dismutase(SOD), and reactive oxygen species(ROS) were also measured.
Results: The concentration of iodine in the urine of the children from high fluoride and iodine,high fluoride,and control group were 721.7,788.3,and 293.5 μg/L and those of fluoride were 2.48,2.70,and 1.59 mg/L. Significant increases in urinary fluoride and iodine were observed in the children of high fluoride and iodine, and high fluoride groups compared to the control group (F=24.1,P=0.000;F=11.0,P=0.000). The concentrations of T4 in the serum of the children from high fluoride and iodine, high fluoride, and control group were 95.0,86.2,and 89.2 ng/L. Thyroid hormone T4 in the children of high fluoride and iodine group was higher than that of high fluoride group (F=4.0, P=0.021), but there were no significant differences in other thyroid hormone (T3, FT3, FT4 and TSH) among the three groups. The concentration of ROS in the serum of children from high fluoride and iodine, high fluoride, and control group were 89.95± 63.85,76.65±125.45, and 72.83± 13.70 U/ mL, and those of the activity of SOD were 2.14±5.20,2.22±2.50,and 0.79±0.90.ROS in the children of high fluoride and iodine group was higher than that in high fluoride group (χ2=14.9,P=0.001), but the activity of SOD demonstrated an inverse trend(χ2=20.9,P=0.000). The difference in MDA was not statistically significant among the groups (χ2=0.9, P=0.626).The content of urinary iodine had a positive correlation with ROS(r=0.226,P=0.026),and an inverse correlation of urinary iodine with SOD was identified(r=-0.264,P=0.009).
Conclusion: The exposure of high fluoride combination with iodine has a definite impact on children's thyroid function, but has no significant impact on another thyroid hormone except T4. Oxidative stress indexes such as ROS and SOD are closely related to urinary iodine and fluoride.
Keywords: fluorosis, high iodine, thyroid, oxidative stress
刘洪亮, 曾强, 侯常春, 等.天津市儿童高碘性甲状腺肿影响因素分析[J].中国公共卫生, 2010, 26(6):684-685.
刘洪亮, 韩树清, 侯常春, 等.天津市地氟病重病区流行病学特征分析[J].中国公共卫生, 2010, 26(3):346-347.
Pearce EN, Gerber AR, Gootnick DB, et al.Effects of chronic iodine excess in a cohort of long-term American workers in west Africa[J].Clin Endocrinol Metab, 2002, 87(12):5499-5502.
Guo HL, Yang XF, Xu J, et al.Effect of selenium on thyroid hormone metabolism in filial cerebrum of mice with excessive iodine[J].Biol Trace Elem Res, 2006, 113(3):281-295.
WHO/UNICEF/ICCIDD.Assessment of iodine deficiency disorders and monitoring their elimination, a guide for programme managers(third edition)[R].Geneva:WHO, 2007:32-34.
中华人民共和国卫生部.WS/T 256-2005 人群尿氟正常值[S].北京:人民卫生出版社, 2005.
刘洋, 杨金, 侯国强, 等.饮水中高碘高氟对8~10岁儿童甲状腺与氟斑牙流行研究[J].中国地方病学杂志, 2011, 10(30):207-208.
巴月, 任丽君, 银功举, 等.饮水氟碘浓度对儿童氟斑牙及甲状腺功能影响[J].中国公共卫生, 2009, 25(8):942-943.
国秀娟, 单忠艳, 腾卫平.氟过量与碘氟过量对甲状腺功能和形态影响的实验研究[J].中华内科杂志, 2006, 45(10):846-847.
Hara K.Studies on fluorosis especially effects of fluoride on thyroid metablism[J].Shikouk Eisei Gakkai Zasshi, 1980, 30(1):42-57.
曾强, 崔玉山, 张磊, 等.氟对甲状腺细胞凋亡的影响及机制研究[J].中华预防医学杂志, 2012, 46(3):233-236.
Basha PM, Rai P, Begum S.Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats:a multigenerational assessment[J].Biol Trace Elem Res, 2011, 144(1-3):1083-1094.
Al-Gubory KH, Garrel C, Faure P, et al.Roles of antioxidant enzymes in corpus luteum rescue from reactive oxygen species-induced oxidative stress[J].Reprod Biomed Online, 2012, 25(6):551-560.
2014: Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin
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