2007 - COL1A2 - Iodine & Fluoride

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2007 - COL1A2 - Iodine & Fluoride

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Hui Huang, Xin-Mei Jia, Shi-Hong L - "Relationship of COL1A2 Polymorphism to Children's Dental Fluorosis" Chinese J Public Health 23(4):445-447 (2007)
https://www.airitilibrary.com/Publicati ... -445-447-a


Objective To explore the distribution of collagen type 1 alpha2 (COL1A2)Pvu Ⅱ genotype in children who lived in the high fluoride, high iodine areas, and evaluate the relationship of COL1A2 Pvu Ⅱ gene polymorphism to children's dental fluorosis. Methods Polymerase chain reaction-restriction fragment length polymorphism technique(PCR-RFLP) was used to determine COL1A2 Pvu Ⅱ genotype of the different children lived in the normal fluoride and iodine area, the high fluoride area, the high fluoride and high iodine area. The incidence of dental fluorosis was examined by using Dean's method. Results The distribution frequency of COL1A2 Pvu Ⅱ genotype was PP23.3%, Pp36.7%, pp40.0% in the normal fluoride and iodine area, PP9.8%, Pp45.1%, pp45.1% in the high fluoride area, and PP13.7%, Pp38.4%, pp47.9% in the high fluoride and high iodine area respectively. There were no significant differences in the three areas(χ^2=5.191, P>0.05). The prevalence of dental fluorosis in these three groups was 0,52.7% 50.7% respectively, and there were significant differences in the three areas(χ^2=49.081, P<0.05). There was no significant difference of children dental fluorosis between the high fluoride area and the high fluoride and iodine area(χ^2=0.060, P>0.05), but the community fluorosis index(CFI) in the high fluoride and iodine area was lower than that in the high fluoride area. Conclusion There were no correlation between COL1A2 Pvu Ⅱ gene polymorphism and the dental fluorosis in the three areas.
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