Sabitha, Suneetha, Mohanty S, Rao P - "Serum anti-TPO levels in benign and malignant breast tumors" Indian J Clin Biochem 24(3):266-8 (2009) doi: 10.1007/s12291-009-0050-x
https://link.springer.com/article/10.10 ... 009-0050-x
"This area of endemic fluorosis has a high incidence of subclinical hypothyroidism (2-10%). This geographical area has also a very high incidence of breast cancer (16.2%). The drinking water level of fluoride is 5.2 ppm in this area."
Dalledone M, Cunha AS, Ramazzotto LA, Pecharki GD, Nelson-Filho P, Scariot R, Trevilatto PC, Vieira AR, Küchler EC, Brancher JA - "Estrogen receptor gene is associated with dental fluorosis in Brazilian children" Clin Oral Investig 23(9):3565-3570 (2019). doi: 10.1007/s00784-018-2778-2
https://link.springer.com/article/10.10 ... 018-2778-2
Maras M, Vanparys C, Muylle F, Robbens J, Berger U, Barber JL, Blust R, De Coen W - "Estrogen-like properties of fluorotelomer alcohols as revealed by mcf-7 breast cancer cell proliferation" Environ Health Perspect 114(1):100-5 (2006). doi: 10.1289/ehp.8149
https://pubmed.ncbi.nlm.nih.gov/16393665/
"We observed small but relevant up-regulation of the estrogen receptor as a consequence of exposures to 6:2 FTOH or 8:2 FTOH. The latter finding suggests an alternative mode of action of the fluorotelomer alcohols compared with that of E2. This study clearly underlines the need for future in vivo testing for specific endocrine-related end points."
Ma Q, Huang H, Sun L, Zhou T, Zhu J, Cheng X, Duan L, Li Z, Cui L, Ba Y - "Gene-environment interaction: Does fluoride influence the reproductive hormones in male farmers modified by ERα gene polymorphisms?" Chemosphere 188:525-531 (2017). doi: 10.1016/j.chemosphere.2017.08.166
https://preview.ncbi.nlm.nih.gov/pubmed/28910727
Liu Q, Liu Y, Li X, Wang D, Zhang A, Pang J, He J, Chen X, Tang NJ - "Perfluoroalkyl substances promote breast cancer progression via ERα and GPER mediated PI3K/Akt and MAPK/Erk signaling pathways" Ecotoxicol Environ Saf 258:114980 (2023) . doi: 10.1016/j.ecoenv.2023.114980
https://www.sciencedirect.com/science/a ... 1323004840
"Two estrogen receptors (ER), ERα and G protein-coupled estrogen receptor (GPER), mediated the promoting effects of PFOA by activating MAPK/Erk and PI3K/Akt signaling pathways. These pathways were regulated by ERα and GPER in MCF-7 cells or independently by GPER in MDA-MB-231 cells. Overall, our study provides a better overview of the mechanisms associated with PFASs-induced breast cancer development and progression."
Chakraborty A, Pramanik S, Datta K, Goswami R, Saha D, Majumdar KK, Sikdar N - "Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal" Biol Trace Elem Res 200(11):4641-4653 (2022) doi: 10.1007/s12011-021-03072-8
The best model of MDR analysis with maximized testing accuracy involved two SNPs from the ESR1 gene (rs9340799 and rs2077647) and one SNP from BGLAP gene (rs1543294) (P value < 0.0001).
Dou Q, Bai Y, Li Y, Zheng S, Wang M, Wang Z, Sun J, Zhang D, Yin C, Ma L, Lu Y, Zhang L, Chen R, Cheng Z - "Perfluoroalkyl substances exposure and the risk of breast cancer: A nested case-control study in Jinchang Cohort" Environ Res 262(Pt 2):119909 (2024). doi: 10.1016/j.envres.2024.119909.
https://linkinghub.elsevier.com/retriev ... 24)01814-0
"Exposures to specific PFAS components were positively associated with an increased incidence risk of breast cancer...Random forests showed that PFBA, PFOS, PFHxS, and PFDA emerged as predominant factors potentially influencing breast cancer incidence....Our findings suggest a strong association between PFAS exposure and the incidence of breast cancer. Premenopausal women should exercise more caution regarding PFAS exposure."