TSH, TT4 and TT3 and fluoride in water

Chinese Studies

TSH, TT4 and TT3 and fluoride in water

Postby admin » Sun Jun 21, 2020 11:02 am

199. 高氟摄入对儿童TT3、TT4和TSH水平的影响

Effect of high fluoride intake on TT3, TT4 and TSH levels in children

向杰 ; 南京医科大学附属口腔医院 江苏省口腔医院 ; 向杰 ; 涂青云 ; 陈冲 ; 丁甘玲 ; 覃玉 ; 梅予锋 ; 向全永 ; 南京医科大学附属口腔医院 江苏省口腔医院,江苏南京210029 ; 向杰口腔诊所 ; 东南大学公共卫生学院 ; 江苏省疾病预防控制中心 ; 南京医科大学附属口腔医院 江苏省口腔医院,江苏南京,210029

江苏预防医学 ; 2019年 04期 (2019 / 11 / 07) , P383 - 385,392
http://www.cnki.com.cn/Article/CJFDTota ... 904009.htm


目的 探讨高氟摄入对儿童血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)和促甲状腺素(TSH)水平的影响,为地方性氟中毒防治提供参考依据.方法 选择1个地方性氟中毒重病区村和1个非病区村为调查点,调查点所有在校的8~13岁儿童为调查对象(外地转入、有明显甲状腺疾病及代谢性疾病者除外),对其氟斑牙患病情况进行调查,检测血清TT3、TT4和TSH水平,并用Student-T、x2检验等方法对资料进行流行病学分析.结果 重病区儿童氟斑牙患病率为85.37%,非病区为6.82%,差异有统计学意义(x2=105.94,P<0.001);重病区儿童家庭饮用水氟含量为(2.36±0.70) mg/L,高于非病区的(0.36±0.10) mg/L,差异有统计学意义(t=-26.47,P<0.001);儿童的血清TT3、TT4和TSH含量,重病区分别为(1.42±0.28) ng/mL、(9.67±1.76)μg/dL和(3.88±2.15) μIU/mL,非病区分别为(1.47±0.33) ng/mL、(9.22±2.54) μg/dL和(2.54±2.07) μIU/mL,其中TSH水平差异有统计学意义(t=3.604,P<0.001).饮水氟和血清氟含量与TSH含量均有显著的负相关性(P值均<0.01).重病区村氟斑牙不同患病程度组儿童的TT3和TSH水平差异均有统计学意义(t值分别为-4.680、-2.57,P值均<0.05).结论 高氟暴露可引起甲状腺功能异常,不同的氟斑牙患病程度儿童血清中的甲状腺素水平差异有统计学意义.
==========

Xiang Jie, Tu Qingyun, Chen Chong, et al. - "Effect of high fluoride intake on TT3, TT4 and TSH levels in children" Jiangsu Preventive Medicine (4):383-385,392 (2019)
http://www.cnki.com.cn/Article/CJFDTota ... 904009.htm

Xiang Jie; Stomatological Hospital of Nanjing Medical University; Jiangsu Stomatological Hospital; Xiang Jie; Tu Qingyun; Chen Chong; Ding Ganling; Qin Yu; Mei Yufeng; Xiang Quanyong; Stomatological Hospital of Nanjing Medical University; Jiangsu Provincial Stomatological Hospital, Nanjing 210029; Xiang Jie Dental Clinic; School of Public Health, Southeast University; Jiangsu Center for Disease Control and Prevention; Stomatological Hospital of Nanjing Medical University, Jiangsu Provincial Stomatological Hospital, Nanjing, Jiangsu 210029

Jiangsu Preventive Medicine; 2019 04 (2019 / 11 / 07), P383-385,392

Effect of high fluoride intake on children's TT3, TT4 and TSH levels

[Abstract]: Objective To explore the effect of high fluoride intake on children's serum total triiodothyronine (TT3), total thyroxine (TT4) and thyrotropin (TSH) levels, to provide a reference for the prevention and treatment of endemic fluorosis . Methods One endemic fluorosis village and one non-endemic village were selected as the survey site. All 8 to 13-year-old children in the survey site were selected as the survey objects (transferred from other places, those with obvious thyroid disease and metabolic disease) Except), investigate the prevalence of dental fluorosis, detect serum TT3, TT4 and TSH levels, and use the Student-T, χ~2 test and other methods to analyze the data epidemiologically. Results The prevalence of children with dental fluorosis was 85.37% in severely ill areas and 6.82% in non-endemic areas, the difference was statistically significant (χ~2=105.94, P0.001); the fluoride content of drinking water for children in seriously ill areas was (2.36± 0.70) mg/L, which is higher than (0.36±0.10) mg/L in the non-disease area, the difference is statistically significant (t=-26.47, P0.001); children's serum TT3, TT4 and TSH content, severely ill area, respectively (1.42±0.28) ng/mL, (9.67±1.76) μg/dL and (3.88±2.15) μIU/mL, the non-disease areas are (1.47±0.33) ng/mL, (9.22±2.54) μg/dL And (2.54±2.07) μIU/mL, of which the difference in TSH level was statistically significant (t=3.604, P0.001). Drinking water fluoride and serum fluoride content had a significant negative correlation with TSH content (all P values ​​were 0.01). There were statistically significant differences in TT3 and TSH levels among children with different degrees of dental fluorosis in severely ill villages (t values ​​were -4.680, -2.57, and P values ​​were 0.05). Conclusion High fluoride exposure can cause abnormal thyroid function. The difference of thyroxine levels in serum of children with different dental fluorosis levels is statistically significant.

[Author Unit] : Jiangsu Stomatological Hospital Affiliated to Nanjing Medical University, Jiangsu Provincial Stomatological Hospital, Xiangjie Dental Clinic , School of Public Health, Southeast University, Jiangsu Provincial Center for Disease Control and Prevention
[Fund]: National Natural Science Foundation of China (81273015)
admin
Site Admin
 
Posts: 1937
Joined: Tue Jan 18, 2005 10:25 pm

Return to Science: China

Who is online

Users browsing this forum: No registered users and 1 guest