High Fluoride/High Iodine & Dental Fluorosis

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高氟高碘饮水对天津市农村学龄儿童氟斑牙患病的影响
Combined influence of high fluoride and high iodine in drinking water on prevalence of dental fluorosis in school-age children in the countryside of Tianjin
王睿 ； 300011,天津市疾病预防控制中心环境与健康所 ； 王睿 ； 曾强 ； 侯常春 ； 崔维琪 ； 张磊 ； 冯宝佳 ； 赵亮 ； 崔玉山 ； 刘洪亮
中华地方病学杂志 ； 2014年 06期 (2014 / 12 / 25) ， P630 - 632
https://d.wanfangdata.com.cn/periodical ... U1bXEyZ240

Wang R, Zeng Q, Hou C, et al. - "Combined influence of high fluoride and high iodine in drinking water on prevalence of dental fluorosis in school-age children in the countryside of Tianjin" Chinese Journal of Endemiology 33(6):630-632 (2014) PFPC Library
https://d.wanfangdata.com.cn/periodical ... U1bXEyZ240
https://www.researchgate.net/publicatio ... of_Tianjin

目的 观察高氟高碘饮水对天津市农村学龄儿童氟斑牙患病的影响.方法 依据天津市农村饮用水中氟含量和碘含量的筛查结果,在天津市选择静海县和武清区的3个乡镇分别作为高氟高碘组、高氟适碘组及适氟适碘(对照)组,以8～10岁农村儿童作为调查对象,采集晨尿,氟离子选择电极法(WS/T 89-1996)检测尿氟,砷铈催化分光光度法(WS/T 107-2006)测定尿碘,采用Dean法检查氟斑牙患病情况.应用SPSS 11.5软件对数据进行x2检验、Logistic分析.结果 高氟高碘组、高氟适碘组及对照组儿童尿氟中位数分别为2.48、2.70、1.59 mg/L,尿碘中位数分别为721.7、788.3、293.5 μg/L,组间比较,差异均有统计学意义(x2值分别为35.10、17.01,P均＜0.05).氟斑牙检出率由高至低依次为高氟适碘组(85.3％,29/34)、高氟高碘组(66.7％,14/21)、对照组(48.8％,21/43),组间比较差异有统计学意义(×2=15.39,P＜0.05).Logistic分析表明,高水氟是氟斑牙的患病危险因素[比值比(OR)为7.273,95％可信区间(CI)为1.676 ～ 31.562,x2=7.020,P＜0.05].结论 饮水高氟及高氟高碘慢性暴露对氟斑牙检出率产生一定的影响.

Objective
To investigate the joint effects of excessive fluoride and iodine in drinking water on school-age children's dental fluorosis in the countryside of Tianjin.

Methods
Based on the screening results of fluorine and iodine contents in drinking water in rural areas of Tianjin, three towns in Jinghai County and Wuqing District of Tianjin were selected as high fluoride and high iodine group, high fluoride and suitable iodine group, and suitable fluoride and suitable iodine (control) group. Children aged 8‒10 were selected as survey subjects. Morning urine was collected and dental fluorosis was examined. The concentration of urinary iodine was determined using arsenic cerium catalytic spectrophotometry (WS/T 107-2006), and urinary fluoride was detected using fluoride ion selective electrode method (WS/T 89-1996). The Dean method was used to check the prevalence of dental fluorosis.

Results
The median urinary iodine was 721.7, 788.3, and 293.5 μg/L, respectively, and the median urinary fluoride was 2.48, 2.70, and 1.59 mg/L, respectively. Urinary iodine and fluoride were the highest in the high fluoride and high iodine group, followed by the high fluoride and suitable iodine group and the control group (χ2 = 35.10, 17.01, all P ＜ 0.05). There was a significant difference in the prevalence of dental fluorosis among the three groups (χ2 = 15.39, P ＜ 0.05). The prevalence of dental fluorosis was the highest in the high fluoride and suitable iodine group (85.3％, 29/34), followed by the high fluoride and high iodine group (66.7％, 14/21) and the control group (48.8％, 21/43). Multiple logistic regression analysis showed that the prevalence of dental fluorosis was adversely associated with fluoride concentration in drinking water [OR = 7.273, 95％ confidence limits (CI): 1.676 ～ 31.562, χ2 = 7.020, P ＜ 0.05].

Conclusion
Drinking water with high fluoride and exposure to high fluoride combined with high iodine has a definite impact on children's dental fluorosis.

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Other studies on same cohort:

Cui Y, Zhao L, Zeng Q, Wang R, Zhang L, Fu G, Feng B, Liu H - "The role of oxidative stress in thyroid injury induced by high iodine and high fluoride levels" Environmental and Occupational Medicine 33(1):7-12 (2016)
https://doi.org/10.13213/j.cnki.jeom.2016.15284

Liu HL, Wang R, Zeng Q, Hou C, Zhao L, Zhang L, Cui Y, Feng B - "Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin" Tianjin Center for Disease Control (2012)

Wang R - "Effects of high fluoride and high iodine combination on thyroid damage and mental development" Master's Thesis, Tianjin University (2010)
https://kns.cnki.net/kcms/detail/detail ... VOaGo6_xMt