Ma Q, Huang H, Sun L, Zhou T, Zhu J, Cheng X, Duan L, Li Z, Cui L, Ba Y 0- "Gene-environment interaction: Does fluoride influence the reproductive hormones
in male farmers modified by ERα gene polymorphisms?" Chemosphere 188:525-531 (2017). doi: 10.1016/j.chemosphere.2017.08.166. Epub
2017 Sep 8.
The occurrence of endemic fluorosis is derived from high fluoride levels in
drinking water and industrial fumes or dust. Reproductive disruption is also a
major harm caused by fluoride exposure besides dental and skeletal lesions.
However, few studies focus on the mechanism of fluoride exposure on male
reproductive function, especially the possible interaction of fluoride exposure
and gene polymorphism on male reproductive hormones. Therefore, we conducted a
cross-sectional study in rural areas of Henan province in China to explore the
interaction between the estrogen receptor alpha (ERα) gene and fluoride exposure
on reproductive hormone levels in male farmers living in the endemic fluorosis
villages. The results showed that fluoride exposure significantly increased the
serum level of estradiol in the hypothalamic-pituitary-testicular (HPT) axis in
male farmers. Moreover, the observations indicated that fluoride exposure and
genetic markers had an interaction on serum concentration of follicle-stimulating
hormone and estradiol, and the interaction among different loci of the ERα gene
could impact the serum testosterone level. Findings in the present work suggest
that chronic fluoride exposure in drinking water could modulate the levels of
reproductive hormones in males living in endemic fluorosis areas, and the
interaction between fluoride exposure and ERα polymorphisms might affect the
serum levels of hormones in the HPT axis in male farmers.
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