Chang Q, Li Z - "Study of toxic effect of fluoride on reproduction of female mice and development of their offspring" Guangdong Medical Journal 23(4):353-355 (2002)
https://eng.oversea.cnki.net/kcms/detai ... J200204005
【Abstract in Chinese】 目的 探讨氟过量和碘不足在妊娠前后这一特殊阶段对亲子两代甲状腺的影响。方法 成年雌性小鼠分别在碘充足和碘相对缺乏的情况下于孕期及孕前自由饮用200 mg/L含氟水,观察两代小鼠甲状腺形态与功能的变化,并记录实验过程中胎（仔）鼠的体重变化。结果 在碘充足的情况下,孕期摄氟组母子两代的血T4浓度、孕18 d母鼠和7日龄仔鼠体重均高于对照组（P<0.01或0.001）;碘相对缺乏的情况下,孕期摄氟组母子两代的血T4浓度和7日龄仔鼠体重显著低于对照组（P<0.05～P<0.01）。各实验组甲状腺形态的定性和定量指标的变化与功能的变化相一致。结论 高氟对亲子两代甲状腺的形态与功能均存在一定影响,碘与其他微量元素的相对缺乏可能促进过量氟的不良影响。它们的共同作用还影响到子代的发育,这与其对甲状腺的影响有关。
【Abstract】 Objective To discuss the effects of high-fluoride intake and iodine-deficiency on thyroid glands of pregnant mice and their offspring. Methods 200 mg/ L sodium fluoride solution was supplied ad.lib. for the adult female Kunming mice before pregnancy and during pregnancy with iodine-sufficiency and iodine-deficiency. The morphological changes and functions of thyroid glands and the body weights of the pregnant mice and their offspring were observed and measured. Results Under the condition of iodine-sufficiency, significantly higher levels of blood T4 in pregnant mice exposed to high-dose fluoride and their offspring were observed compared with those of control group. Significantly heavier body weights were found in 18 d-pregnant mice and 7 d-old offspring compared with those of control group (P<0.01 or P<0.001). Under the condition of iodine-deficiency, significantly lower levels of blood T4 were found in the pregnant mice exposed to high-dose fluoride and their offspring compared with those of control group. Significantly lower levels of body weights were observed in 7 d-old offspring compared with those of control group( P<0.05, P<0.01 or P<0.001) . The indexes, qualitative and quantitative, reflecting the morphological changes of thyroid glands of the mice in each group were consistent with the changes of the functional indexes of thyroid glands. Conclusion Over intake of fluoride revealed a certain impairment on the morphology and function of thyroid glands of the pregnant mice and their offspring. The relative deficiency of iodine and other trace elements might enhance the adverse effects induced by over intake of fluoride. The combination of over intake of fluoride and deficiency of iodine could affect the development of offspring which might be associated with the thyroid glands damaged.
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