1998 - Effects of fluoride/selenium on rat thyroid function

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1998 - Effects of fluoride/selenium on rat thyroid function

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143. 郭晓尉,卢传华,边建朝;氟硒对大鼠甲状腺组织及功能的影响[J];微量元素与健康研究;1998年04期
http://lib.cnki.net/cjfd/WYJK804.004.html

观察了饮用高氟水及加硒大鼠的甲状腺组织结构和甲状腺激素变化。结果表明,早期甲状腺滤泡上皮细胞增生活跃、游离甲状腺激素水平显著升高;后期甲状腺滤泡上皮细胞出现退行性变,FT3和T4水平明显降低;补硒与甲状腺激素水平有一定关系。提示高氟在早期使甲状腺兴奋,甲功高度代偿,后期则抑制甲状腺使甲功低下;氟与甲状腺组织及功能的改变与摄氟时间密切相关。
admin
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Re: 1998 - Effects of fluoride/selenium on rat thyroid funct

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【Abstract】: The changes of thyroid tissue and thyroid hormones in rats drinking high-fluorine water and selenium were observed. The results showed that the proliferation of thyroid follicular epithelial cells was active early, and the level of free thyroid hormone was significantly increased. In the later stage, thyroid follicular epithelial cells showed degenerative changes, and the levels of FT3 and T4 were significantly reduced. Selenium supplementation has a certain relationship with thyroid hormone levels. It is suggested that high fluoride excites the thyroid gland in the early stage, and the nail function is highly compensated. In the later stage, it inhibits the thyroid gland to make the nail function lower. Fluorine changes in thyroid tissue and function are closely related to the time of fluoride ingestion.

NOTE: First increase - then decrease. (Just like TSH)
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