© 2020 - 2023 PFPC
COVID-19
Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Liu Y, Zhou Y, Lan K, Chen Y - "Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients" Emerg Microbes Infect 9(1):761-770 (2020). doi: 10.1080/22221751.2020.1747363. PMID: 32228226; PMCID: PMC7170362"SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia". (Xiong et al., 2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170362/
Singh N, Bharara Singh A - "S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study" Transl Oncol 3(10):100814 (2020) doi: 10.1016/j.tranon.2020.100814
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324311/
Zhang S, El-Deiry WS - "Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure" Oncotarget 15:275-284 (2024) doi: 10.18632/oncotarget.28582
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073320/
Zhang Y, Peng X, Xue M, Liu J, Shang G, Jiang M, Chen D, Liu B, Wang Y, Jia X, Xu J, Zhang F, Hu Y - "SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway" Biogerontology 24(5):813-827 (2023). doi: 10.1007/s10522-023-10019-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898700/
Bordoni V, Tartaglia E, Sacchi A, Fimia GM, Cimini E, Casetti R, Notari S, Grassi G, Marchioni L, Bibas M, Capobianchi MR, Locatelli F, Maeurer M, Zumla A, Antinori A, Nicastri E, Ippolito G, Agrati C - "The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients" Int J Infect Dis 105:49-53 (2021) doi: 10.1016/j.ijid.2021.02.019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872850/
Wang X, Liu Y, Li K, Hao Z - "Roles of p53-Mediated Host-Virus Interaction in Coronavirus Infection" Int J Mol Sci 24(7):6371 (2023). doi: 10.3390/ijms24076371
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094438/
"During viral infection, p53 is activated and initiates a cascade of events that result in cell cycle arrest. Specifically, activated p53 mediates the protein p21 to form complexes with CDKs, resulting in the inhibition of cyclin–CDK activity."
Fluoride
"Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers." (Wen et al., 2019)
Wen P, Wei X, Liang G, Wang Y, Yang Y, Qin L, Pang W, Qin G, Li H, Jiang Y, Wu Q - "Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers." Environ Sci Pollut Res Int 26(3):2671-2680 (2019). doi: 10.1007/s11356-018-3726-z. Epub 2018 Nov 26. PMID: 30478774
https://link.springer.com/article/10.10 ... 018-3726-z
"Fluoride overexposure is an environmental health hazard and can cause enamel and skeletal fluorosis. Previously we demonstrated that fluoride increased acetylated-p53 and its downstream target p21 in ameloblast-derived LS8 cells.... Inhibition of MDM2-mediated p21 degradation may be a potential therapeutic target to mitigate fluoride toxicity." (Deng et al., 2019)
Deng H, Ikeda A, Cui H, Bartlett JD, Suzuki M - "MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts" Cells 8(5):436 (2019) doi: 10.3390/cells8050436. PMID: 31083332; PMCID: PMC6562432.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562432/
Suzuki M, Ikeda A, Bartlett JD - " Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation" Arch Toxicol 92(3):1283-1293 (2018)"The SIRT1/p53 pathway may be a potential therapeutic target for dental fluorosis."(Suzuki et al., 2017)
https://www.ncbi.nlm.nih.gov/pmc/articl ... 67832/#R27
Qing-Feng S, Ying-Peng X, Tian-Tong X - "Matrix metalloproteinase-9 and p53 involved in chronic fluorosis induced blood-brain barrier damage and neurocyte changes" Arch Med Sci 15(2):457-466 (2019) doi: 10.5114/aoms.2019.83294. Epub 2019 Mar 4. PMID: 30899299; PMCID: PMC6425220
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425220/
Xiang J, Qi XL, Cao K, Ran LY, Zeng XX, Xiao X, Liao W, He WW, Hong W, He Y, Guan ZZ - "Exposure to fluoride exacerbates the cognitive deficit of diabetic patients living in areas with endemic fluorosis, as well as of rats with type 2 diabetes induced by streptozotocin via a mechanism that may involve excessive activation of the poly(ADP ribose) polymerase-1/P53 pathway" Sci Total Environ 169512 (2023). doi: 10.1016/j.scitotenv.2023.169512. Epub ahead of print
How is Gq/11 involved?
"Immune responses are coordinated by the extracellular ligand to GPCR on lymphocytes, and activated intracellular Gq protein then activates enzymes, second messengers, protein kinases, and nuclear translocation, consequently inducing the migration, activation, and apoptosis of lymphocytes [48]. This well-orchestrated function of hematopoietic cells is complex; however, it is clear that Gq-coupled receptors and the signaling molecules that reside downstream of these receptors are critical to these functions." (Zhang & Shi, 2016; Molon et al, 2005)
Molon B, Gri G, Bettella M, Gómez-Moutón C, Lanzavecchia A, Martínez-A C, Mañes S, Viola A - "T cell costimulation by chemokine receptors" Nat Immunol 6(5):465-71 (2005)
https://pubmed.ncbi.nlm.nih.gov/15821738/
Solyakov L, Sayan E, Riley J, Pointon A, Tobin AB - "Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor." Oncogene 28(41):3619-30 (2009). doi: 10.1038/onc.2009.225
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875175/
"In the current study we demonstrate that a classical Gq/11-coupled GPCR, the M3-muscarinic receptor, was able to regulate apoptosis via receptors that are endogenously expressed in the human neuroblastoma cell line SH-SY5Y and when ectopically expressed in Chinese hamster ovary (CHO) cells. Stimulation of the M3-muscarinic receptor was shown to inhibit the ability of the DNA-damaging chemotherapeutic agent, etoposide, from mediating apoptosis. This protective response in CHO cells correlated with the ability of the receptor to regulate the expression levels of p53."
- SEE: Willson CM, Lequio M, Zhu Z, Wakefield MR, Bai Q, Fajardo E, Xiao H, Leung S, Fang Y - "The Role of SARS-CoV-2 Spike Protein in the Growth of Cervical Cancer Cells" Anticancer Res 44(5):1807-1815 (2024). doi: 10.21873/anticanres.16982
https://ar.iiarjournals.org/content/44/5/1807.long
"The anti-proliferative effect of SARS-CoV-2 SP on SiHa cancer cells was associated with the up-regulation of the anti-proliferative molecule p53."
https://www.hindawi.com/journals/jir/2016/3969023/
https://doi.org/10.1155/2016/3969023
p53 and thyroid hormones
Zou M, Baitei EY, Al-Rijjal RA, Parhar RS, Al-Mohanna FA, Kimura S, Pritchard C, Binessa HA, Alzahrani AS, Al-Khalaf HH, Hawwari A, Akhtar M, Assiri AM, Meyer BF, Shi Y - "TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer" Oncogene 35(15):1909-18 (2016) doi: 10.1038/onc.2015.253. Epub 2015 Oct 19. PMID: 26477313; PMCID: PMC6310059.
Xian H, Wang F, Teng W, Yang D, Zhang M - "Thyroid hormone induce a p53-dependent DNA damage through PI3K/Akt activation in sperm" Gene 615:1-7 (2017) doi: 10.1016/j.gene.2017.03.014. Epub 2017 Mar 16. PMID: 28322991.
======================================
Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N - "The p53 tumor suppressor targets a novel regulator of G protein signaling" Proc Natl Acad Sci U S A 94(15):7868-72 (1997) doi: 10.1073/pnas.94.15.7868. PMID: 9223279; PMCID: PMC21521.
https://pubmed.ncbi.nlm.nih.gov/9223279
"Overexpression of A28-RGS14p protein inhibits both Gi- and Gq-coupled growth-factor-receptor-mediated activation of the mitogen-activated protein kinase signaling pathway in mammalian cells. Thus, through the induction of A28-RGS14, p53 may regulate cellular sensitivity to growth and/or survival factors acting through G protein-coupled receptor pathways."
SEE ALSO: p21. viewtopic.php?f=66&t=1928
p53 & Fluoride: viewtopic.php?f=7&t=6009