2002 - Effects of fluoride and iodine on developing brain

2002 - Effects of fluoride and iodine on developing brain

Postby admin » Sun Aug 18, 2013 1:10 am

96. 詹平,罗子国, 碘、氟对大鼠子代脑发育形态学改变联合作用的研究, 预防医学情报杂志 2002 18(3):193-194,196
http://d.wanfangdata.com.cn/periodical_ ... 03001.aspx
Zhan et al . - "Combined effects of fluoride and iodine on morphological changes in the developing rat brain" Journal of Preventive Medicine 18(3):193-194,196 (2002)

目的观察碘、氟对大鼠子代脑发育形态学方面是否存在联合作用.方法将实验用Wistar成年大鼠雌16只,雄8只,按饮水中不同碘、氟或碘+氟浓度分为8组,即:碘、氟为0(对照组,采用重蒸水),碘0.5、1.0、2.0mg/L,氟50 mg/L,碘+氟0.5+50、1.0+50、2.0+50 mg/L.喂养90 d后相同浓度组雌、雄按2∶1合笼交配,交配后2l~28 d母鼠产仔,哺乳5 d后将各组仔鼠断头处死.取其脑组织进行大脑重量、光镜(观察大脑皮质神经细胞密度及未分化神经母细胞占细胞总数百分比)、电镜(观察神经元发育情况)等形态学指标检查.结果仔鼠大脑重量及光镜指标经2×4析因方差分析均表明各组之间差异有显著性(P<0.001).其中氟50 mg/L、碘2.0 mg/L及碘+氟2.0+50 mg/L组各项指标都提示仔鼠大脑发育状况次于其余各组.电镜检查发现氟50 mg/L及碘+氟2.0+50 ml/L组神经元发育及超微结构形态有轻微变性改变.结论长期饲以高氟及高碘饮水的大鼠均可影响其子代大脑发育,且高碘、高氟对仔鼠大脑发育的危害存在协同作用.
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