1996 - FX of F- and selenium on pituitary, thyroid - rats

1996 - FX of F- and selenium on pituitary, thyroid - rats

Postby admin » Mon Feb 24, 2014 9:02 am

104. 卢传华,边建朝,叶平,等.过量氟和硒对大鼠垂体、甲状腺甲状旁腺的影响.中国地方病防治杂志,1996,11(1):18
Hua et al. - "Effect of high fluoride and selenium on pituitary gland, thyroid and parathyroid in rats" Chinese Journal of Control of Endemic Diseases 11(1):18 (1996)

为观察过量氟对大鼠垂体、甲状腺、甲状旁腺的影响及硒的保护作用,选用Wistar大鼠饮用30mg/L(1.58mmol/L)与50mg/L(2.63mmol/L)高氟水,同时设高氟水加富硒(se含量2.024mg/kg)饲料组。自实验第4个月光镜下见甲状腺呈现弥漫增生性改变,8个月和14个月出现增生和过度复原并存;垂体4个月光镜下尚无变化,8个月开始出现窦样毛细管增生并扩张充血,嗜酸性细胞变大增多,呈现分化和功能活跃表现;甲状旁腺光镜下自8个月开始见到旁腺增生、主细胞大小及数量增加等机能亢进表现。结果说明,氟中毒对垂体、甲状腺及甲状旁腺的损害是肯定的。本实验还观察到,硒有排氟作用,但未发现对垂体、甲状腺有显著的保护作用。
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