1989 - Fluoride and iodine synergistic FX on rat thyroid

1989 - Fluoride and iodine synergistic FX on rat thyroid

Postby admin » Mon Dec 16, 2013 3:26 am

97. 官志忠,庄宗杰,杨沛施,等.缺碘和氟中毒对大鼠甲状腺的协同作用.中华病理生理杂志,1989,5(3):158-162
http://www.cnki.com.cn/Article/CJFDTOTA ... 903012.htm
Guan ZZ et al.- "Synergistic effects of fluoride and iodine on the thyroid gland in rats" Journal of Pathophysiology 5(3):158-162 (1989)

see also:
Guan ZZ, Zhuang ZJ, Yang PS, Pan S - "Synergistic action of iodine-deficiency and fluorine-intoxication on rat thyroid" Chin Med J (Engl)
101(9):679-84 (1988) PubMed PMID: 3148411.


实验用Wistar大鼠212只,按饮食中碘和氟含量不同随机分为五组,实验期为7个月。结果显示:摄碘正常的大鼠长期饮用30ppm氟水后引起甲状腺功能和形态的严重损害,而饮用10ppm氟水的大鼠仅见甲状腺滤泡上皮超微结构的轻度异常变化;单纯性缺碘大鼠甲状腺肿大并伴有代偿性功能变化,缺碘并饮用10ppm氟水的大鼠在其甲状腺肿大的同时伴有明显的形态结构损伤及甲状腺代偿功能抑制,甚至功能低下。
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