©2006 PFPC
A select list of 40+ papers from the international literature documenting the use and efficacy of fluoride as an antithyroid medication in iodine-induced hyperthyroidism (Jod Basedow). Included are studies on tablets, baths, ointments, eggs, injections, as well as organic fluoride preparations. Please note the many papers from the 1930s - long before artificial fluoridation supplementation programs were considered. The effects of fluoride on iodine metabolism were well-known at the time.
Casterra H - "Erfahrungen mit einem neuen organischen Fluorpräparat bei Hyperthyreosen" [Experiences with a new organic fluoride preparation for hyperthyroidism] Das Deutsche Gesundheitswesen 2(22):704-705 (1947)
Christiani H - "Altération de la glande thyroïde dans l'intoxication fluorée" [Alteration of the thryoid gland in fluoride poisoning] Compt Rend Soc Biol 103:554–556 (1930)
Galletti PM, Joyet G - "Effect of fluoride on thyroidal iodine metabolism in hyperthyroidism" J Clin Endocrinol 18:1102-1110 (1958)
Galletti PM, Joyet G, Jallut O - "Effets du fluorure de sodium sur la fonction thyröidienne dans la maladie de Basedow" [Effect of sodium fluoride on thyroid function in Basedow's disease] Helv Med Acta 24(3):209-15 (1957)
Goldemberg L - "Action physiologiques des fluorines" [Physiological action of fluorides] Compt Rend Soc de Biol (Paris) 95:1169 (1926)
Goldemberg L - "Tratamiento de la enfermedad de Basedow y del hipertiroidismo por el fluor" [Treatment of Basedow disease and of hyperthyroidism with fluorine] Prensa Med Arg 17:690-700 (1930) Rev Soc Med Int Soc Tisiol 6:217-42 (1930)
- See also:
Goldemberg L - "Traitement de la maladie de Basedow et de 'hyperthyroidisme par le fluor" Presse Méd 102:1751 (1930)
Goldemberg L, Maggi H - "Episodio agudo gravisimo de tirotoxicosis en una enferma de Basedow, curado con las inyecciones intravenosas de fluoruro de sodio" [Very serious acute episode of thyrotoxicosis in a Basedow patient, cured with intravenous injections of sodium fluoride] Prensa Med Arg 18:169-170 (1931), Rev Soc Med Int Soc Tisiol 7:289-292 (1931)
Goldemberg L - "Comment agiraient-ils therapeutiquement les fluorures dans le goitre exophtalmique et dans l'hyperthyroidisme? Technique actuelle du traitement fluorique" [How would fluorides act therapeutically in exophthalmic goiter and hyperthyroidism? Current technique of fluoride treatment] Semana Md 1:659-665 (1932)
Goldemberg L - "La fluorterapia por via endovenosa produce el descanso y la normalizacion de la eritrosedimentacion acelerada de los hipertiroideos" [Intravenous fluoride therapy affects the erythrocyte sedimentation which had been accelerated in hyperthyroid patients rate to return to normal] Prensa Med Arg 20:2589-721 (1933) Rev Soc Arg Biol 9:550-554 (1933)
Goldemberg L - "Treatment of cardiac insufficiency in Basedow’s disease with intravenous injections of sodium fluoride" Bull Acad Med 119:39-45 (1938)
Goldemberg L - "Five years of treatment of hyperthyroidism with fluoride" Semana Med (Buenos Aires) 11:1273-9 (1934) (C.A. 29:511,1935)
Goldemberg L - "Results obtained in foreign countries with the treatment of exopthalmic goiter with fluoride" La Semana Med (Buenos Aires) II:2106 (1933)
Goldemberg L, Schraiber J - "El contenido en fluor de los humores (sangre, liquido céfaloraquideo, etc.), del organismo humano en diversos estados patologicos" [The fluorine content of the humors (blood, cerebrospinal fluid, etc.), of the human organism in various pathological states] Rev Soc Argent Biol 11:39-45 (1935)
Gorlitzer von Mundy V - "Ein neuer Weg zur Behandlung der Thyreotoxikose mit Fluorwasserstoffsäure" [A new way to treat hyperthyroidism with hydrofluoric acid] Med Klin Wschr 21:717-719 (1932)
Gorlitzer von Mundy V - Med. Klin.47:911 (1952), also cited in Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" [Influence of fluorine and iodine on metabolism, especially on the thyroid] Münch Med Wochensschr 105:182-186 (1963)
Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" Münch Med Wochensschr 105:182-186 (1963); also in Gordonoff, T. - Fluor und die Schilddrüse, Toxikology des Fluors Basel/Stuttgart, pp.111-123 (1964)
Hodenberg, Frhr v - "Die Behandlung der Hyperthyreose mit Fluortyrosin" [The treatment of hyperthyroidism with fluorotyrosine] Deut Med Wochschr 67:706-9 (1941)
Hosoi T, Okura E - "Fluorwasserstoff-Badekur und innere Anwendung von Borax bei Basedowscher Krankheit und Hyperthyreoidismus" [Hydrogen fluoride spa treatment and internal use of borax in Basedow disease and hyperthyroidism] [in Japanese] Journal of Kyoto Prefectural University of Medicine 22(1):754-760 (1938)
Inouye Y, Yamaga T, Simizu K, Otani K - "Therapeutische Anwendung der Fluorwasserstoff-lontophorese bei der Basedowkrankheit und Hypertonia" [Therapeutic application of hydrogen fluoride iontophoresis in Basedow disease and hypertonia] Japan J Med Sci VIII, Internal Med Pediat Psychiat 5 Proc 104-108 (1938)
Inouye Y, Yamaga T, Maeda S - "Schwankungen der Werte von Jod, Fluor, anorganischen Salzen und von Zucker im Blut bei der Fluorwasserstoff-Iontophorese" [Fluctuations in the levels of iodine, fluorine, inorganic salts and sugar in the blood during hydrogen fluoride iontophoresis] Japan J Med Sci VIII Internal Med, Pediat Psychiat 5:Proc. 149 (1939)
Kraft K - "Beiträge zur Biochemie des Fluors I. Über den Antagonismus zwischen Fluor und Thyroxin" [Contributions to the biochemistry of fluoride I. On the antagonism between fluoride and thyroxine] Hoppe-Seglers Z.Physiol. Chem 245:58 -65 (1937)
Litzka G - "Die experimentellen Grundlagen der Behandlung des Morbus Basedow und der Hyperthyreose mittels Fluortyrosin" [The experimental basis of the treatment of Basedow disease and hyperthyroidism with fluorotyrosine] Med Wochenschr 63:1037-1040 (1937)
Litzka G - "Erfolgskontrolle bei Behandlung der Schilddrüsenüberfunktion" ["Success control in the treatment of hyperthyroidism] Z. klin. Med.131:791-799 (1937)
Litzka G - "Die antithyreotoxische Wirkung des Fluortyrosins" [The antithyreotoxic effect of fluorotyrosine] Arch. exp. Pathol. u. Pharmakol. 183:436-458 (1936)
Litzka G - "Fluortyrosine" Klin Wochenschr. 15:1568-1569 (1936)
Litzka G - "Allgemeine biologische Wirkungen einer kernfluorierten Aminosaeure (Fluortyrosin)" [General biological effects of a nuclear-fluorinated amino acid (fluorotyrosine)] Arch exp Pathol u. Pharmakol 183:427-435 (1936)
Maccioro G - "La fluorterapia nel morbo di FlaJani-Basedow"[Fluorine therapy in Flajani-Basedow's Disease] Riforma med. 48:1436-46 (1932)
May W, Schwarz B - "Die Basedow-Behandlung mit Fluor. Vorlaufige Mitteilung." [Treatment of Basedow with fluoride: Preliminary Notice] Fortschr. Med 50:563-564 (1932)
May W - "Antagonismus zwischen Jod und Fluor im Organismus" [Antagonism between iodine and fluorine in the organism] Klin Wochenschr 14:790-792 (1935)
May W - "Behandlung the Hyperthyreosen einschliesslich des schweren genuinen Morbus Basedow mit Fluor" [Treatment of hyperthyroidism with fluoride, including severe, genuine Morbus Basedow] Klin Wochenschr 16:562-564 (1937)
May W - "Eine neue interne Behandlung der Hyperthyreosen einschließlich des Morbus Basedow" [A New Internal Treatment For Hyperthyroidism Including Morbus Basedow] Diskussionsvortrag, Verhandlungen der Deutschen Gesellschaft für innere Medizin, 49.Kongress, Wiesbaden, March 15-18, 1937, München (1937)
May W, Litzka G - "Über die Hemmung des Tumorwachstums durch Fluortyrosine" [About the inhibition of tumor growth by fluorotyrosine] Z. Krebsforschung 48:376 - 382 (1939)
May W - "Die Behandlung der Hyperthyeosen mit Fluortyrosine" [The treatment of hyperthyroidism with fluorotyrosine] Deutsch Med Wochenschr 68:164 (1942)
May W - "Die Basedowsche Krankheit" [Basedow Disease] Aulendorf (1950)
May W - "Fluor als Therapeuticum" [Fluoride as a therapeutic agent] Arzneimittel Forschung 1:33-37 (1951)
May R - "Therapie mit organischen Fluorverbindungen" [Therapy with organic fluorides] Med Wochenschr 4:489-490 (1950)
May R - "Erfahrungen in der Behandlung von Hyperthyreose- und Basedow-Kranken mit einer organischen Fluorverbindung (Fluoroxyphenylessigsäure, 'Capacin')" [Experience in the treatment of hyperthyroid and Basedow patients with an organic fluorine compound (fluoroxyphenylacetic acid, 'Capacin')] Deutsche Med. Wochenschr.74(12):374-375 (1949)
Orlowski W - "Sur la valeur therapeutique du sang animal du bore et du fluor dans la maladie de Basedow" [On the therapeutic value of animal blood of boron and fluoride in Basedow disease] La Presse Medicale 42:836-837 (1932)
Purjesz B, Berkessy L, Gönczi K, Kovacs-Oskolas M - "Über die biologische Speicherung der halogenen Elemente in Hühnereiern und im tierischen Organismus" [About the biological storage of the halogen elements in chicken eggs and in the animal organism] Arch Exp Pathol Pharmakol 176:578-582 (1934)
Raveno WS - "Fluorides as an aid to iodine in hyperthyroidism" J Mich State Med Soc 33:359-63 (1934)
Schutte J - "Fluorine therapy in hyperthyroidism and in some symphatheticotonic neuroses" Arch Med Interna Habana 1, No. 3 (1935)
Woakes E - "The pathogeny and treatment of bronchocele or goitre" Lancet 1:448-50;497-498;537-538 (1881)
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Note: Goldemberg used ammonium fluoride 8 mgs/day = 4.1 mg fluoride