2014 - Resveratrol Against Fluoride-Induced Thyroid Alt

All adverse health effects of fluoride are related to thyroid hormone metabolism.
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2014 - Resveratrol Against Fluoride-Induced Thyroid Alt

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Sarkar C, Pal S - "Ameliorative Effect of Resveratrol Against Fluoride-Induced
Alteration of Thyroid Function in Male Wistar Rats" Biol Trace Elem Res. 2014 Aug
28. [Epub ahead of print] PubMed PMID: 25164033
http://link.springer.com/article/10.100 ... 8-3#page-2

Resveratrol (3,4,5-trihydroxystilbene), a polyphenol and well-known natural
antioxidant has been evaluated for its protective effect against fluoride-induced
metabolic dysfunctions in rat thyroid gland. Fluoride, the most abundant anions
present in groundwater throughout the world, creates a major problem in safe
drinking water and causes metabolic, structural, and functional injuries in
different organ systems. Sub-acute exposure to sodium fluoride at a dose of
20 mg/kg b.w./day orally to rat for 30 days induces thyroidal dysfunction
including suppressed synthetic machinery of the thyroid gland to produce nucleic
acids and thyroid hormones, mainly T3 and T4. Other functional changes are
alteration of certain metabolic enzyme activities like Na(+)-K(+)-ATPase, thyroid
peroxidase, and 5,5'-deiodinase. Structural abnormality of thyroid follicles by
fluoride intoxication clearly indicates its thyrotoxic manifestation. Resveratrol
supplementation in fluoride-exposed animals appreciably prevented metabolic
toxicity caused by fluoride and restored both functional status and
ultra-structural organization of the thyroid gland towards normalcy. This study
first establishes the therapeutic efficacy of resveratrol as a natural
antioxidant in thyroprotection against toxic insult caused by fluoride.
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