The mechanisms leading to Dental Fluorosis remain unknown...
Posted: Sat Aug 17, 2013 7:14 am
©1996-2024 PFPC
"Excessive fluoride intake during enamel development can affect enamel mineralization, leading to dental fluorosis. However, its potential mechanisms remain largely unexplored."
Bi R, Sun Y, Xiang L, Xu Z, Ye X, Tian Y, Lin Y, Yang C, Gao Y - "TGF-β1/Smad3 Signaling Is Required to Alleviate Fluoride-Induced Enamel Hypomineralization" Biol Trace Elem Res 202(2):569-579 (2024). doi: 10.1007/s12011-023-03688-y
"The precise mechanism via which fluoride induces the alterations that result in enamel fluorosis remains unclear..."
Sidhu S, Kathuria N, Mahajan B, Sidhu GK, Ramalingam K - "Prevalence and Distribution of Developmental Defects of Enamel in Children Aged 12–15 Years in Fazilka District, Punjab, India, and Their Correlation With Drinking Water Fluoride Level" Cureus 15(12): e51238 (2023) doi:10.7759/cureus.51238
"The underlying mechanism of fluorosis has not been fully elucidated."
Yu FF, Yu SY, Duan LZ, Yang S, Hou XB, Du YH, Gao MH, Zuo J, Sun L, Fu XL, Li ZY, Huang H, Zhou GY, Jia DL, Chen RQ, Ba Y - "Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride" Biol Trace Elem Res (2023 Aug 16) doi:10.1007/s12011-023-03805-x
"Presently, the pathogenesis of DF remains unclear."
Zhang K, Lu Z, Guo X - "Advances in epidemiological status and pathogenesis of dental fluorosis" Front Cell Dev Biol 11:1168215 (2023) doi: 10.3389/fcell.2023.1168215
"...the mechanisms underlying fluoride-induced enamel damage are still not fully elucidated."
Yao S, Weng Q, Zhu Y, Liu J, Luo Y, Da D, Zhang Y - "Excessive fluoride impairs autophagy flux in ameloblasts which is prevented by the autophagy activator rapamycin" Environ Toxicol 38(1):193-204 (2023)
"However, the pathogenesis mechanism underlying dental fluorosis has not been fully clarified."
Gong QM, Ling JQ, Wei X - "Research progress in the pathogenesis mechanism of dental fluorosis" Chinese Journal of Stomatology 58(3):217-223 (2023)
"Excess consumption of fluoride during the development of tooth enamel will cause dental fluorosis, but the exact molecular mechanisms remain to be elucidated."
Zou T, Ma L, Gu L, Xi S, Zhang K, Guo X - "Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis" Chem Biol Interact 367:110145 (2022)
"Clearly, dental fluorosis remains a world health issue, and despite decades of research, the proximate causes remain unclear."
Costiniti V, Bomfim GH, Mitaishvili E, Son GY, Li Y, Lacruz RS - "Calcium transport in specialized dental epithelia and its modulation by fluoride" Front Endocrinol (Lausanne) 12:730913 (2021)
"...the pathogenesis of dentin fluorosis and its mechanisms are poorly understood."
Kao YH, Igarashi N, Abduweli Uyghurturk D, Li Z, Zhang Y, Ohshima H, MacDougall M, Takano Y, Den Besten P, Nakano Y - "Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice" Biol Trace Elem Res 199(8):3021-3034 (2021)
"Although there are multiple causes of dental fluorosis, the precise mechanism remains controversial."
Ji M, Duan X, Han X, Sun J, Zhang D - "Exogenous transforming growth factor-β1 prevents the inflow of fluoride to ameleoblasts through regulation of voltage-gated chloride channels 5 and 7" Exp Ther Med 21(6):615 (2021)
"Despite decades of research on DF, the cellular mechanisms directly responsible for this disease remain poorly understood."
Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE 2nd, Idaghdour Y, Yule DI, Lacruz RS - "Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells" Sci Signal 13(619):eaay0086 (2020)
"There are multiple potential causes of dental fluorosis; however, the precise mechanism by which dental fluorosis occurs remain controversial."
Ji M, Xiao L, Xu L, Huang S, Zhang D - "How pH is regulated during amelogenesis in dental fluorosis" Exp Ther Med 16(5):3759-3765 (2018)
"Treatments to prevent fluorosis and the molecular pathways responsive to fluoride exposure remain to be elucidated."
Suzuki M, Ikeda A, Bartlett JD - "Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation" Arch Toxicol 92(3):1283-1293 (2018)
"Fluoride excess of 0.05-0.07 mgF/kgbw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet."
Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers ALJJ - "Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors" Arch Oral Biol 83:214-221 (2017)
"The mechanism of dental fluorosis is very complex and not fully understood."
Ullah R, Zafar MS, Shahani N - "Potential fluoride toxicity from oral medicaments: A review" Iran J Basic Med Sci 20(8):841-848 (2017)
"The mechanisms by which excessive ingestion of fluoride (F) during amelogenesis leads to fluorosis are still not precisely known."
Charone S, De Lima Leite A, Peres-Buzalaf C, Silva Fernandes M, Ferreira de Almeida L, Zardin Graeff MS, Cardoso de Oliveira R, Campanelli AP, Groisman S, Whitford GM, Everett ET, Buzalaf MA - "Proteomics of Secretory-Stage and Maturation-Stage Enamel of Genetically Distinct Mice" Caries Res 50(1):24-31 (2016)
"...the mechanism of dental fluorosis remains unclear."
Lei S, Zhang Y, Zhang K, Li J, Liu L - "Effects of Fluoride on the Expression of Beclin1 and mTOR in Ameloblasts" Cells Tissues Organs 200(6):405-12 (2015)
"...the underlying mechanism is unclear."
Wei W, Gao Y, Wang C, Zhao L, Sun D "Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion" Environ Toxicol. 28(6):332-41 (2013)
"Currently the molecular mechanism responsible for dental fluorosis remains unknown..."
Sierant ML, Bartlett JD -"Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis" Cells 1(3):631-645 (2012)
"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Chaturvedi R, Kaur M, Gauba K, Bhalla S - "Dental Fluorosis: An update" Indian J Dent Ed 4(1/2):23 (2011)
"The molecular mechanisms that underlie dental fluorosis are poorly understood."
Sharma R, Tye CE, Arun A, MacDonald D, Chatterjee A, Abrazinski T, Everett ET, Whitford GM, Bartlett JD - "Assessment of dental fluorosis in Mmp20 +/- mice" J Dent Res 90(6):788-92 (2011)
"The exact mechanism through which dental fluorosis develops is not fully understood."
Wong MC, Glenny AM, Tsang BW, Lo EC, Worthington HV, Marinho VC - "Topical fluoride as a cause of dental fluorosis in children" Cochrane Database Syst Rev 2010(1):CD007693 (2010)
"The mechanisms by which fluoride affects enamel formation to result in fluorosis are not fully understood."
Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P - "Effects of fluoride on the interactions between amelogenin and apatite crystals" J Dent Res 87(1):39-44 (2008)
"...the mechanism of F(-)-induced toxicity is unclear."
Sharma R, Tsuchiya M, Bartlett JD - "Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion" Environ Health Perspect 116(9):1142-6 (2008)
"...the precise mechanisms are unclear.”
Moseley R, Waddington RJ, Sloan AJ, Smith AJ, Hall RC, Embery G - "The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model" Calcified Tissue International 73:470-5 (2003)
"The molecular mechanisms that underlie the pathogenesis of dental fluorosis are not known.”
Everett ET, McHenry MA, Reynolds N, Eggertsson H, Sullivan J, Kantmann C, Martinez-Mier EA, Warrick JM, Stookey GK - "Dental fluorosis: variability among different inbred mouse strains" J Dent Res. 81(11):794-8 (2002)
"....the exact mechanism leading to dental fluorosis is not fully understood.”
Susheela AK, Bhatnagar M. - "Structural aberrations in fluorosed human teeth: Biochemical and scanning electron microscopic studies"
Current Science 77:1677-80 (1999)
"The specific mechanisms by which fluoride causes the changes leading to enamel fluorosis are not well defined."
DenBesten PK - "Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements." Community Dent.Oral Epidemiol 27:41–47 (1999)
"How the fluoride disturbs the intracellular transport of the cell in forming the mottled enamel is still unknown."
Matsuo S, Kiyomiya K, Kurebe M - "Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride" Arch Toxicol 72(12):798-806 (1998)
"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Wright JT, Chen SC, Hal KI, Yamauchi M, Bawden JW - "Protein Characterization of Fluorosed Human Enamel." Dent Res 75(12):1936 (1996)
"The action of fluoride on tooth development and the observed side-effects of fluorosis are not yet fully understood."
Veron MH, Couble ML - "The biological effects of fluoride on tooth development: possible use of cell culture systems" Int Dent J 42(2):108-12 (1992)
"The mechanism underlying the development of dental fluorosis remains unknown."
Angmar-Månsson B, Whitford GM -"Enamel Fluorosis Related to Plasma F Levels in the Rat" Caries Research 18(1):25–32 (1984) doi:10.1159/000260743
etc.
"Excessive fluoride intake during enamel development can affect enamel mineralization, leading to dental fluorosis. However, its potential mechanisms remain largely unexplored."
Bi R, Sun Y, Xiang L, Xu Z, Ye X, Tian Y, Lin Y, Yang C, Gao Y - "TGF-β1/Smad3 Signaling Is Required to Alleviate Fluoride-Induced Enamel Hypomineralization" Biol Trace Elem Res 202(2):569-579 (2024). doi: 10.1007/s12011-023-03688-y
"The precise mechanism via which fluoride induces the alterations that result in enamel fluorosis remains unclear..."
Sidhu S, Kathuria N, Mahajan B, Sidhu GK, Ramalingam K - "Prevalence and Distribution of Developmental Defects of Enamel in Children Aged 12–15 Years in Fazilka District, Punjab, India, and Their Correlation With Drinking Water Fluoride Level" Cureus 15(12): e51238 (2023) doi:10.7759/cureus.51238
"The underlying mechanism of fluorosis has not been fully elucidated."
Yu FF, Yu SY, Duan LZ, Yang S, Hou XB, Du YH, Gao MH, Zuo J, Sun L, Fu XL, Li ZY, Huang H, Zhou GY, Jia DL, Chen RQ, Ba Y - "Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride" Biol Trace Elem Res (2023 Aug 16) doi:10.1007/s12011-023-03805-x
"Presently, the pathogenesis of DF remains unclear."
Zhang K, Lu Z, Guo X - "Advances in epidemiological status and pathogenesis of dental fluorosis" Front Cell Dev Biol 11:1168215 (2023) doi: 10.3389/fcell.2023.1168215
"...the mechanisms underlying fluoride-induced enamel damage are still not fully elucidated."
Yao S, Weng Q, Zhu Y, Liu J, Luo Y, Da D, Zhang Y - "Excessive fluoride impairs autophagy flux in ameloblasts which is prevented by the autophagy activator rapamycin" Environ Toxicol 38(1):193-204 (2023)
"However, the pathogenesis mechanism underlying dental fluorosis has not been fully clarified."
Gong QM, Ling JQ, Wei X - "Research progress in the pathogenesis mechanism of dental fluorosis" Chinese Journal of Stomatology 58(3):217-223 (2023)
"Excess consumption of fluoride during the development of tooth enamel will cause dental fluorosis, but the exact molecular mechanisms remain to be elucidated."
Zou T, Ma L, Gu L, Xi S, Zhang K, Guo X - "Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis" Chem Biol Interact 367:110145 (2022)
"Clearly, dental fluorosis remains a world health issue, and despite decades of research, the proximate causes remain unclear."
Costiniti V, Bomfim GH, Mitaishvili E, Son GY, Li Y, Lacruz RS - "Calcium transport in specialized dental epithelia and its modulation by fluoride" Front Endocrinol (Lausanne) 12:730913 (2021)
"...the pathogenesis of dentin fluorosis and its mechanisms are poorly understood."
Kao YH, Igarashi N, Abduweli Uyghurturk D, Li Z, Zhang Y, Ohshima H, MacDougall M, Takano Y, Den Besten P, Nakano Y - "Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice" Biol Trace Elem Res 199(8):3021-3034 (2021)
"Although there are multiple causes of dental fluorosis, the precise mechanism remains controversial."
Ji M, Duan X, Han X, Sun J, Zhang D - "Exogenous transforming growth factor-β1 prevents the inflow of fluoride to ameleoblasts through regulation of voltage-gated chloride channels 5 and 7" Exp Ther Med 21(6):615 (2021)
"Despite decades of research on DF, the cellular mechanisms directly responsible for this disease remain poorly understood."
Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE 2nd, Idaghdour Y, Yule DI, Lacruz RS - "Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells" Sci Signal 13(619):eaay0086 (2020)
"There are multiple potential causes of dental fluorosis; however, the precise mechanism by which dental fluorosis occurs remain controversial."
Ji M, Xiao L, Xu L, Huang S, Zhang D - "How pH is regulated during amelogenesis in dental fluorosis" Exp Ther Med 16(5):3759-3765 (2018)
"Treatments to prevent fluorosis and the molecular pathways responsive to fluoride exposure remain to be elucidated."
Suzuki M, Ikeda A, Bartlett JD - "Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation" Arch Toxicol 92(3):1283-1293 (2018)
"Fluoride excess of 0.05-0.07 mgF/kgbw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet."
Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers ALJJ - "Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors" Arch Oral Biol 83:214-221 (2017)
"The mechanism of dental fluorosis is very complex and not fully understood."
Ullah R, Zafar MS, Shahani N - "Potential fluoride toxicity from oral medicaments: A review" Iran J Basic Med Sci 20(8):841-848 (2017)
"The mechanisms by which excessive ingestion of fluoride (F) during amelogenesis leads to fluorosis are still not precisely known."
Charone S, De Lima Leite A, Peres-Buzalaf C, Silva Fernandes M, Ferreira de Almeida L, Zardin Graeff MS, Cardoso de Oliveira R, Campanelli AP, Groisman S, Whitford GM, Everett ET, Buzalaf MA - "Proteomics of Secretory-Stage and Maturation-Stage Enamel of Genetically Distinct Mice" Caries Res 50(1):24-31 (2016)
"...the mechanism of dental fluorosis remains unclear."
Lei S, Zhang Y, Zhang K, Li J, Liu L - "Effects of Fluoride on the Expression of Beclin1 and mTOR in Ameloblasts" Cells Tissues Organs 200(6):405-12 (2015)
"...the underlying mechanism is unclear."
Wei W, Gao Y, Wang C, Zhao L, Sun D "Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion" Environ Toxicol. 28(6):332-41 (2013)
"Currently the molecular mechanism responsible for dental fluorosis remains unknown..."
Sierant ML, Bartlett JD -"Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis" Cells 1(3):631-645 (2012)
"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Chaturvedi R, Kaur M, Gauba K, Bhalla S - "Dental Fluorosis: An update" Indian J Dent Ed 4(1/2):23 (2011)
"The molecular mechanisms that underlie dental fluorosis are poorly understood."
Sharma R, Tye CE, Arun A, MacDonald D, Chatterjee A, Abrazinski T, Everett ET, Whitford GM, Bartlett JD - "Assessment of dental fluorosis in Mmp20 +/- mice" J Dent Res 90(6):788-92 (2011)
"The exact mechanism through which dental fluorosis develops is not fully understood."
Wong MC, Glenny AM, Tsang BW, Lo EC, Worthington HV, Marinho VC - "Topical fluoride as a cause of dental fluorosis in children" Cochrane Database Syst Rev 2010(1):CD007693 (2010)
"The mechanisms by which fluoride affects enamel formation to result in fluorosis are not fully understood."
Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P - "Effects of fluoride on the interactions between amelogenin and apatite crystals" J Dent Res 87(1):39-44 (2008)
"...the mechanism of F(-)-induced toxicity is unclear."
Sharma R, Tsuchiya M, Bartlett JD - "Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion" Environ Health Perspect 116(9):1142-6 (2008)
"...the precise mechanisms are unclear.”
Moseley R, Waddington RJ, Sloan AJ, Smith AJ, Hall RC, Embery G - "The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model" Calcified Tissue International 73:470-5 (2003)
"The molecular mechanisms that underlie the pathogenesis of dental fluorosis are not known.”
Everett ET, McHenry MA, Reynolds N, Eggertsson H, Sullivan J, Kantmann C, Martinez-Mier EA, Warrick JM, Stookey GK - "Dental fluorosis: variability among different inbred mouse strains" J Dent Res. 81(11):794-8 (2002)
"....the exact mechanism leading to dental fluorosis is not fully understood.”
Susheela AK, Bhatnagar M. - "Structural aberrations in fluorosed human teeth: Biochemical and scanning electron microscopic studies"
Current Science 77:1677-80 (1999)
"The specific mechanisms by which fluoride causes the changes leading to enamel fluorosis are not well defined."
DenBesten PK - "Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements." Community Dent.Oral Epidemiol 27:41–47 (1999)
"How the fluoride disturbs the intracellular transport of the cell in forming the mottled enamel is still unknown."
Matsuo S, Kiyomiya K, Kurebe M - "Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride" Arch Toxicol 72(12):798-806 (1998)
"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Wright JT, Chen SC, Hal KI, Yamauchi M, Bawden JW - "Protein Characterization of Fluorosed Human Enamel." Dent Res 75(12):1936 (1996)
"The action of fluoride on tooth development and the observed side-effects of fluorosis are not yet fully understood."
Veron MH, Couble ML - "The biological effects of fluoride on tooth development: possible use of cell culture systems" Int Dent J 42(2):108-12 (1992)
"The mechanism underlying the development of dental fluorosis remains unknown."
Angmar-Månsson B, Whitford GM -"Enamel Fluorosis Related to Plasma F Levels in the Rat" Caries Research 18(1):25–32 (1984) doi:10.1159/000260743
etc.