The Mechanisms leading to DF remain unknown...

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"...the mechanism of dental fluorosis remains unclear."
Lei S, Zhang Y, Zhang K, Li J, Liu L - "Effects of Fluoride on the Expression of Beclin1 and mTOR in Ameloblasts" Cells Tissues Organs 200(6):405-12 (2015)

"Currently the molecular mechanism responsible for dental fluorosis remains unknown..."
Sierant ML, Bartlett JD -"Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis" Cells 1(3):631-645 (2012)

"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown"
Wright JT, Chen SC, Hal KI, Yamauchi M, Bawden JW - "Protein Characterization of Fluorosed Human Enamel." Dent Res 75(12):1936 (1996)

"..the underlying mechanism is unclear."
Wei W, Gao Y, Wang C, Zhao L, Sun D "Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion" Environ Toxicol. 28(6):332-41(2013)

"The mechanisms by which fluoride affects enamel formation to result in fluorosis are not fully understood."
Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P - "Effects of fluoride on the interactions between amelogenin and apatite crystals" J Dent Res 87(1):39-44 (2008)

"...the precise mechanisms are unclear.”
Moseley R, Waddington RJ, Sloan AJ, Smith AJ, Hall RC, Embery G - "The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model" Calcified Tissue International 73:470-5 (2003)

"The molecular mechanisms that underlie the pathogenesis of dental fluorosis are not known.”
Everett ET, McHenry MA, Reynolds N, Eggertsson H, Sullivan J, Kantmann C, Martinez-Mier EA, Warrick JM, Stookey GK - "Dental fluorosis: variability among different inbred mouse strains" J Dent Res. 81(11):794-8 (2002).

"....the exact mechanism leading to dental fluorosis is not fully understood.”
Susheela AK, Bhatnagar M. - "Structural aberrations in fluorosed human teeth: Biochemical and scanning electron microscopic studies"
Current Science 77:1677-80 (1999)

"...the mechanism of F(-)-induced toxicity is unclear."
Sharma R, Tsuchiya M, Bartlett JD - "Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion" Environ Health Perspect 116(9):1142-6 (2008)

"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Chaturvedi R, Kaur M, Gauba K, Bhalla S - "Dental Fluorosis: An update" Indian J Dent Ed 4(1/2):23 (2011)

etc. etc.