Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009)
(Area with excessine iodine ingestion)
Objective To explore the effect of drinking high fluoride on thyroid function in children. Methods The high-fluorine drinking water area and the control area were selected as the survey points, and the children aged 8 to 12 years old who were born and raised in the area were selected as the survey objects. According to the diagnostic criteria for goiter in GB16004-1995, goiter was diagnosed, and radioimmunoassay was used to determine free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone in serum. TSH) Three hormone levels. Results The urinary fluoride content of children in the high fluoride area was 2.09 mg/L, and the urinary fluoride content of children in the control area was 0.83 mg/L, the difference was statistically significant (p0.05); the urinary iodine content of children in the high fluoride area was 294.85 mg/L L, the urine iodine content of children in the control area was 468.82 mg/L, the difference between the two was statistically significant (P0.05); the concentration of serum FT3 in children in the high fluoride area was 5.73 pmol/L, and the concentration of serum FT 3 in the control area was 4.60 pmol/L, the difference between the two was statistically significant (P0.05); the concentration of children's serum FT4 in the high fluoride area was 7.40 pmol/L, and the concentration of children's serum FT4 in the control area was 8.07 pmol/L, and there was no difference between the two Academic significance (p0.05); the concentration of children's serum TSH in the high fluoride area was 1.03 pmol/L, and the concentration of children's serum TSH in the control area was 1.10 pmol/L, the difference between the two was not statistically significant (p0.05); high fluoride There was no significant difference in children's goiter between the area and the control area (p0.05). Conclusion High fluoride in drinking water can affect the serum FT3 level in children.
UF: 2.09 - Control: 0.83 mg/L
UI: 294.85 - Control: 468.82 mg/L
FT4: 7.40 pmol - Control: 8.07 pmol
FT3: 5.73 pmol - Control: 4.60 pmol
TSH: 1.03 - Control: 1.10
I in Water: 76.3 g/L. Control: 91.80 g/L
F in water: 1.80 Control: <1 mg/L whatever that means...?
However, the urinary iodine content of children in the control area of this study was higher than that of children with high fluoride
area, and the difference was statistically significant (P<0.05). and adjusted
companion study:
1.1 对象 以河南省开封、通许县各 2个村庄作为调查点。
选择平均水碘 浓度为 291.3mg/L、平均水 氟浓度为 3.9
基金项目:河南省医学科技攻关项 目(20060374)
作者单位 :1.郑州大学 公共卫 生学 院环境卫生学 教研室 ,河 南 郑
州 450001;2.河南省开封 市疾病 预防控 制中心 ;3.河
南省疾病 预防控制 中心
作者简介 :巴月(1963一),女 ,河南郑州人 ,副教授 ,博士 ,硕士生导
师,主要从事环境相关疾病的人群易感性研究。
mg/L的开 封 县 某村 为 高氟 高 碘 区 ;选 择 平 均 水 碘 浓 度 为
351.1Ixg/L、平均水氟浓度 <1.0mg/L的该县另一个村作为
单纯高碘 区;选择平均水碘浓度为 91.8 g/L、平均水 氟浓度
为 1.8mg/L的通许 县某村 为单纯 高 氟区 ;选择平 均水碘 浓
度 76.3Ixg/L、平均水 氟浓度 <1.0Ixg/L的该县另一村作 为
对照区。各调查点经济水平、人口结构及生活习惯基本一致。
同时选择 4个调查点本地出生成长 的 8~12岁儿童进行健康
体检。排除肝、肾功能异常及接受氟化物或碘化物治疗,以及
患有影响钙磷代谢疾病和近期服用补钙制剂的儿童。其中高
氟高碘区儿童73人 ,男 35人 ,女 38人 ,平均年龄 10.03岁;
高氟区儿童 71人,男 39人 ,女32人,平均年龄 9.54岁;高碘
区儿童36人 ,男 l9人,女 17人,平均年龄9.62岁;对照区儿
童
Ba Yue , Ren Lijun, Yingong , Cheng Xuemin , Aftermath, Li Shihong, Ji Xiaomei , Zhang Lili , Cui Liuxin - "Effects of Fluoride and Iodine Concentration in Drinking Water on Dental Fluorosis and Thyroid Function in Children" Chin Public Health 8:942-943 (2009)
http://222.198.130.40:81/Qikan/Article/ ... arch_Index
Kaifeng and Tongxu areas
HIGH IODINE. |HIGH I/HIGH F. | HIGH F | CONTROL
simple high I - 351 | I in water 291.3 | I in Water: 76.3 g/L | Control: 91.80 g/L
F<1mg/L | F in water: 3.9. | F in water 1.80 | Control: <1 mg/L whatever that means...?