2010 - Establishment of Animal Model - Fluoride/Iodine

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Establishment of animal model and determination of biochemical indexes of offspring rats exposed to high fluoride and low iodine
【Title】 Establishment of animal model and determination of biochemical indexes of offspring rats exposed to high fluoride and low iodine View Full Text
【Author】 Yaming Ge, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Hongmei Ning, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Junwei Liu, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Junjie Chen, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Qinggong Han, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Hua Zhong, College of Animal Science, Henan Institute of Science and Technology, Xinxiang; Jundong Wang, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Shanxi, China
【Conference Title】 The Third International Conference on Modelling and Simulation(第三屆國際建模、計算、仿真、優化及其應用學術會議 ICMS 2010)　
【Date of Conference】 2010-06-04
【Conference Venue】 無錫
【Organizer】 南京信息工程大學; 江南大學; 南京理工大學
【Literature】 The Third International Conference on Modelling and Simulation(第三屆國際建模、計算、仿真、優化及其應用學術會議 ICMS 2010)論文集
【Publish Time】 2010-06-04
【Pages】 218-222
【Keywords】 Brain protein　Establishment of animal model　High fluoride　Iodine deficiency　MDA　Offspring rats　Rat brain　SOD　
【Abstract】 Thirty-two Wistar rats were divided randomly into four groups of eightrats(female:male=3:1). With one untreated group as controls, the other three groups were administered, respectively, high fluoride in their drinking water(100mg NaF/L), low iodine(0.0855 mg/kg chow), or both high fluoride(100 mg NaF/L) andlow iodine(0.0855 mg/kg) in order to assess the effects of the three treatments on oxidative stress in the brain of offspring rats. After the animal model was established, the rats were allowed to breed, and 36 offspring rats in each group (female:male=1:1)were randomly selected for the experiments. The treatment ofthese rats was the same as their parents. In comparison with control rats, brain protein was decreased by low iodine and even more by the combined interaction of high fluoride and low iodine. Superoxide dismutase(SOD)activity and the malondialdehyde(MDA)content in the brain of the combined high fluoride and low iodine group were significantly higher during and at the end of the 90day period than in the control group,but the SOD/MDA ratio in this high fluoride and low iodine group was consistently lower than in the control group.These results suggest that brain stress from high fluoride and low iodine is one of the causes of reduction in learning and memory in offspring rats.