1997 - Effects of fluoride on maternal thyroid - mice

1997 - Effects of fluoride on maternal thyroid - mice

Postby admin » Tue Jan 05, 2016 3:05 am

179. Chang Qing, Rong Cheng Xing, Zhang Shiming - "Effects of fluoride exposure in female mice on the thyroid's morphology and function as well as ontogeny of fetuses and newborns" Guangdong Anatomy Bulletin" 1997 19(2):17-21
http://www.chemdrug.com/article/7/507/2530182.html
http://www.cnki.com.cn.dincheng.cn/Arti ... 702004.htm
posting.php?mode=post&f=13

通过亲代雌性小鼠在一定时期内自由饮用200mg/L含氟水,使母鼠血氟浓度增高.借助组织形态学方法和放射免疫分析法观察母鼠受高氟因素作用对子代甲状腺形态、功能以及对胚胎甲状腺发生过程的影响.结果表明:母鼠受孕后开始受氟化物作用,其胎(仔)鼠血甲状腺素(T_4)水平和甲状腺滤泡细胞增高度(H)均显著高于正常对照组;亲代母鼠孕前度及孕期长期慢性氟暴露,其胎(仔)鼠在部分取材时间内其T_4和H与对照组有差别,但其变化无明显规律;氟对胚胎甲状腺的发生发育在时间上无明显延迟作用,仅使部分腺体的滤泡成熟次序发生改变.上述结果提示:母体氟暴露对子代甲状腺存在一定的不良影响.
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