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Glutamic Acid Pashaev CA, Aliev AN, Mamedova SA - “Prevention of dental fluorosis by glutamic acid” Stomatologiia (Mosk) 3:9-11 (2003) The preventive effect of glutamic acid on the clinical manifestation of dental fluorosis was studied in rat experiments. Young rats receiving fluorinated (15 mg/liter) drinking water during 4-5 weeks developed depigmentation characteristic of dental fluorosis. No depigmentation was observed in rats receiving water with the same content of fluorine in parallel with glutamic acid (twice a week). The enamel in this latter group virtually did not differ from normal dental enamel in rats receiving standard vivarium rations. Hence, glutamic acid prevented dental fluorosis by neutralizing the toxic effect of high fluorine dose. Biochemical parameters of the blood (Ca, P, total protein, AlAT, AsAT) also indicated the corrective effect of this amino acid. http://www.mediasphera.aha.ru/stomatol/2003/3/e3-03ref. htm DEFINITION: Glutamic Acid DEFINITION: GABA Alfonso M, Duran R, Arufe MC - “Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving rats” Horm Res 54(2):78-83 (2000) Vara H, Martinez B, Santos A, Colino A - “Thyroid hormone regulates neurotransmitter release in neonatal rat hippocampus” Neuroscience 110(1):19-28 (2002) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrie ve&db=pubmed&dopt=Abstract&list_uids=11882369 “In addition, hypothyroid rats exhibit an increase in the Ca(2+)-dependent neurotransmitter release. These alterations are basically reversible when thyroid hormone is administered.” (Vara et al, 2002) Shuaib A, Ijaz S, Hemmings S, Galazka P, Ishaqzay R, Liu L, Ravindran J, Miyashita H - “Decreased glutamate release during hypothyroidism may contribute to protection in cerebral ischemia” Exp Neurol 128(2):260-5 (1994) Chapa F, Kunnecke B, Calvo R, Escobar del Rey F, Morreale de Escobar G, Cerdan S - “Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance” Endocrinology 136(1):296-305 (1995) SEE ALSO: GLUTAMATE GLUTAMINE GABA
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