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In 1970, the World Health Organization published its paper "Fluorides and Human Health", prepared "in consultation with ninety-three dental and medical specialists" - so the title page. Victor Demole authored the section dealing with fluoride effects on the thyroid and thyroid hormones. It is one of the worst reviews ever seen on this subject. Not only does Demole leave out the most important contributors in this field - he outright states untruths as they relate to the actual literature he provides in support for his conclusions. Here is only one example, related to 3-fluoro-thyrosine (called 3-fluoro-thyronine by Demole) Demole writes: "The compound 3-fluoro-thyronine is said to lower the BMR [Basic Metabolic Rate] in mice (Litzka, 1936) and to delay tadpoles' metamorphosis (Kraft, 1936); however, it seems merely ineffectual in the treatment of Graves' disease (May, 1935)." While Litzka and Kaft certainly reported many more very important findings in their papers than those mentioned by Demole, let's concentrate on May. By the way, in this time period measuring tadpole's metamorphosis was the standard test required to prove any preparation to be an Demole cites a May paper from 1935 [Klin. Wochenschrift 14:790 (1935)] as reference for his claim that "3-fluoro-thyronine" is "merely ineffectual in the treatment of Graves' disease". What did May actually say in his paper, entitled, "Antagonism between fluoride and iodine in the organism"? Well, first of all he doesn't mention 3-fluoro-thyronine AT ALL, as his work with this particular compound did not start until shortly after this 1935 paper was published. As to the efficacy of this compound - May treated over 6000 patients with fluoro-thyrosine most successfully, and published on this extensively in peer-reviewed European medical journals, proclaiming it more effective and safe than any other anti-thyroid medication, including PTU. So much for this compound "seeming merely ineffectual". (Keep in mind that this was BEFORE the age of water fluoridation and other supplementation programs...) Anyway, back to this 1935 May paper Demole cites. He DOES talk about the fluoride-iodine antagonism and his very successful fluoride therapy which by this time had involved over 800 patients to whom he had given sodium fluoride tablets or ointments. He also cites the work of many others who had similar results with F- therapy, such as Todd (London), Orlowski (Warsaw), and Gorlitzer As well, no mention what-so-ever is given of Goldemberg - the originator of the fluoride thyroid therapy who had published extensively between 1919 and 1930 on this subject - nor is there mention of Bircher and Repin, Gautier, Clausman, McCarrison, Parhou and Goldstein, Pighini, Christiani, Cahages, Houssay, Schulz, Brandt and Piscotti, Stuber and Lang, etc.. All of these experts are mentioned by May, however. . . As we wrote earlier, Goldemberg had become convinced that the iodine deficiencies observed in countries world-wide were not due to actual iodine deficiency, but excess intake of fluorides. His logical conclusion was that Further, May describes in his paper the existing thesis why fluoride worked in reducing iodine levels in the system. Its mode of action was thought to be via the liver - the main organ for essential T4 to T3 conversion. It was believed that by inhibiting glycolysis in the liver - essential for T4 to T3 conversion - fluoride brought down iodine levels which were measurable in the blood. (It is important to remember that tests at this time were not nearly as developed nor as sensitive as they are now. Most of the breakthroughs in thyroid testing have occurred in the last two to three decades.) May was very much concerned about being able to show fluoride effects on iodine at hand of blood tests. He discusses these tests in this 1935 paper cited by Demole. As a standard test for iodine in blood had not been developed yet, numerous tests then in use were compared. While all tests showed different "normal" levels, the_curve_ was the important factor in all tests, and it showed identical results: the more fluoride - the less iodine in blood. The higher the iodine blood levels - the more fluoride had to be used in therapy. This became a concern for May, as sodium fluoride toxicity had been well observed and documented. He was very happy when it was discovered that organic fluoride compounds were much more efficient in the treatment of this hyperthyroidism. Why was this so important? Reduction of iodine levels in blood meant correction of hyperthyroidism caused by excess iodine consumption. May and others had earlier shown that in ALL the cases of goiter presenting with a group of certain other symptoms there was an elevation of blood iodine levels. the disease became known as Graves disease in the UK, and "Jod Basedow" in Germany, Austria, and Switzerland. May and many of his colleagues were dismayed at authorities for putting iodine in the water supplies to combat iodine deficiency, which had resulted in the epidemic of hyperthyroidism, called "Jod Basedow" in Germany, and "Graves' Disease" in the UK. [Goiter was a major problem for many European countries, resulting in high economic pressure, and the inability for countries to put together effective armies, as so many were afflicted.] May pointed to the fact that one could not simply presume that everyone responded to the same dose of iodine in the same way, due to the by then already well-established "individual thyroid-resistance". No two people responded the same to identical doses of iodine. The same dose which could relieve iodine deficiency in one person could produce hyperthyroidism in another. In addition, some were drinking more water than others....[Sound familiar?] Why would the WHO publish such unscientific rubbish? A look at the contributors involved here gives a clue: Among the "ninety-three dental and medical specialists" listed we find the ususal fluoride polluters and others with huge vested interests: E.J. Largent, advisor for Reynolds Metals; Edward J. Largent worked in the 1940s on a fluoride project supported by - Mead Johnson & Company (Mead Johnson Nutritionals). Mead Johnson Nutritionals was the manufacturer ofinfant formulas (e.g. PABLUM) as well as Harold Hodge (Manhattan Project, 1943-47; Atomic Energy Project, 1947-58) who also became head of the International Association for Dental Research in 1947 (quite a leap!). Hodge's research was also sponsored at a time by the Ozark Mahoning Chemical Company, a company making inorganic fluorine compounds and dentifrice fluoride products, such as sodium monofluorophosphate, its biggest single business. The company had made fluorine chemicals since 1925. J.C. Muhler ("Crest" patent) S. Yngve Ericsson - Professor of the Dental School at the Karolinska Institute, University of Stockholm, one of Europe's most prominent advocates of fluoridation, had been a recipient of US Public Health Service (USPHS) research grants and subsequently received royalities from Sweden's toothpaste industry as he held the patent on MFP in toothpaste. As a further note: Two well-known American proponents, Dr. J.W.Knutson and Professor H.C. Hodge, presented the case to the committee. Some of Hodge's research had been financed by the Ozark Mahoning Chemical Company and some, at the time, by the Atomic Energy Commission -- both of which were confronted with serious environmental fluoride disposal problems. Another member of the "expertcommittee", Professor Yngve Ericsson of the Dental School at the Karolinska Institute, University of Stockholm, one of Europe's most prominent advocates of fluoridation, had been a recipient of US Public Health Service (USPHS) research grants and subsequently received royalities from Sweden's toothpaste industry. All offers of scientific reports establishing the toxicity of fluoride were rejected by the committee. To the credit of the WHO, their 1958 document stated: "This report contains the collective views of an international group of experts and does not necessarily represent the decisions of the stated policy of the WHO." An Analogy to the Secret Vote on the Federal 1949 - Pennsylvania Salt's new plant in Calvert City, KY was completed and began making hydrofluoric acid.) 1958 1960 Pennsalt entered plastics field with development of Kynar® polyvinylidene fluoride resin. 1965 Pennsalt completed plant for production of Kynar® polyvinylide fluoride resin at Calvert City, KY. 1997 - Elf Atochem North America completed construction of its largest plant for the manufacture of Forane® 134a refrigerant in Calvert City, KY. Moodie Fluospar: |
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