Chlorotrifluoroethylene Oligomer: Evaluation of Acute Delayed Neurotoxicity in Hens, and Study of Absorption and Metabolism in Rats Following Oral, Dermal, and Inhalation Exposure

Authors: Kinkead, E. R.; Gaworski, C. L.; Horton, J. R.; Boosinger, T. R.; CALIFORNIA UNIV IRVINE

Abstract: Acute toxicity studies including delayed neurotoxicity, single dose oral, 4- and 6-hour vapor inhalation, and single dose dermal were conducted with the chlorotrifluoroethylene (CTFE) oligomer MLO 83-322. A second sample, MLO 81- 125 from the same lot as MLO 83-322, did not contain the additives and was used only during part of the inhalation study. Hens receiving five consecutive oral doses of up to 9.2 g CTFE/kg body weight remained neurologically asymptomatic through a 30 day observation period. CFTE was readily absorbed and converted to free fluoride following oral and inhalation exposure. Single oral doses of 9.2 g CFTE/kg failed to produce mortality in the test rats. Six-hour saturated vapor exposures to MLO 83-322 resulted in mortality while four-hour exposures caused no deaths. Four-hour inhalation exposures to MLO 81-125 produced deaths at both concentrations tested. CTFE absorption was not evident following dermal exposure. Keywords: Oral toxicity, Inhalation toxicity, Dermal toxicity, Fluoride.

Limitations: APPROVED FOR PUBLIC RELEASE

Description: Technical rept. Apr 84-Jan 86

Pages: 29

Report Date: SEP 87

Report number: A116781

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