Ca & Thyroid

An
Monzani F, Caraccio N, Del Guerra P, Casolaro A, Ferrannini E - “Neuromuscular symptoms and dysfunction in subclinical hypothyroid patients: beneficial effect of L-T4 replacement therapy” Clin Endocrinol (Oxf) 51(2):237-42 (1999)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=104 68996

    “An inverse relationship was observed between ionized calcium and: TSH values (r = -0.69, P = 0.0001); the number of neuromuscular symptoms (r = -0.53, P = 0.0001).”

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Yoneda M, Takatsuki K, Yamauchi K, Oiso Y, Kurokawa M, Kawakubo A, Izuchi K, Tanaka H, Kozawa O, Miura Y, et al - “Influence of thyroid function on serum bone Gla protein” Endocrinol Jpn 35(1):121-9 (1988)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=326 0858

    “Serum BGP had a significant positive correlation with the concentrations of free triiodothyronine and alkaline phosphatase in the serum, while it had a significant negative correlation with serum PTH...These results suggest that thyroid hormone directly stimulates the synthesis and secretion of BGP in existent osteoblasts and also acts on the bone remodeling cycle, therapy accelerating the rate of bone formation; the latter action may occur over a long period.

Urinary calcium => higher in subclinical hyperthyroidism

Urinary calcium excretion is higher in subclinical hyperthyroid patients compared to control and hypothyroid subjects (Bradley et al, 2003).

 Six weeks after the cessation of fluoride
         treatment, the mean serum osteocalcin concentration had returned to the
         pretreatment baseline. We conclude that fluoride administration in normal
         subjects over a short period increases serum osteocalcin concentration
         and probably stimulates osteoblastic activity.


         http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3266960&dopt=Abs tract

         Clin Endocrinol (Oxf) 1988 Oct;29(4):437-41

         Sodium fluoride stimulates osteocalcin in normal subjects.

         Dandona P, Coumar A, Gill DS, Bell J, Thomas M.

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Poppe K, Verbruggen LA, Velkeniers B, Finne E, Body JJ, Vanhaelst L - “Calcitonin reserve in different stages of atrophic autoimmune thyroiditis” Thyroid 9(12):1211-4 (1999)