A previous PFPC comment focused on the fact that the NRC used TSH reference levels which were 4 years out of date. [Click here]

  What is perhaps even more astounding is the NRC’s complete failure to disclose/discuss that fluoride has been used in hundreds of laboratory investigations specifically as a thyroid-stimulating-hormone (TSH) analogue [=> acts like TSH].

  Instead, the NRC writes:



DeEds F, Wilson RH, Cutting WC - "Thyrotropic hormone and fluorine activity" Endocrinology 26(6):1053-1056 (1940)

Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G - "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families" Proc Natl Acad Sci U S A ;93(1):116-20 (1996) http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8552586

TSH and the 2006 NRC Review
© 2006 PFPC

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