Throughout the 2006 NRC Review there are sections dealing with
While all of it “sounds” scientific, the issue is actually so poorly understood
that at times one can only shake one‘s head in disbelief - how can the “highest scientific authority in the US” publish such gibberish?
Consider this example:
Under the Section: Neurotoxicity and Neurobehavioral Effects
Using slices of rat neocortex, Jope (1988) found that NaF stimulated the hydrolysis of phosphoinositide by
activation of a G protein, Gp. This protein acts as transducer between receptors and phospholipase C. (NRC Review, Page 219)
It appears that many of fluoride's effects, and those of the aluminofluoride complexes are mediated by
activation of Gp, a protein of the G protein family. (NRC Review, page 222)
There is no such G protein called "Gp".
The G protein(s) the NRC should be discussing are called Gq/11.
It is Gq/11 which activate phospholipase C and which are responsible for the modulation of phosphoinositide hydrolysis as reported
by Jope et al. (1994; 1997), as well as many others.
Gq/11 have been established to be the transducing G proteins for all Ca(2+)-mobilizing receptors (i.e. Exton, 1993).
There are hundreds, if not thousands on studies, showing the effects of fluoride and clarifying the biochemical effects
not only on the brain, but also on bone, dental fluorosis, etc.., most of them implicating Gq/11 - which are NOT pertussin-sensitive G proteins.
What is needed is NOT more research, but a scientific panel which actually understands the matter which it has
been asked to review.
For more info, please see:
Gq/11 (PFPC password required)
Exton JH - "Role of G proteins in activation of phosphoinositide phospholipase C" Adv Second Messenger
Phosphoprotein Res 28:65-72 (1993)
Jope RS, Song L, Powers R - "[3H]PtdIns hydrolysis in postmortem human brain membranes is mediated by the G-proteins
Gq/11 and phospholipase C-beta" Biochem J 304 ( Pt 2):655-9 (1994)
Jope RS, Song L, Li X, Powers R - "Impaired phosphoinositide hydrolysis in Alzheimer's disease brain" Neurobiol Aging
Jope RS, Song L, Powers RE - "Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease
brain" Neurobiol Aging 18